SCHEMBL24316658

SCHEMBL24316658

COc1ccc(COc2ncc(Oc3ccc4ncc(N)c(=O)n4c3)cc2C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 4/20 0.42
ALKBH1 Q13686 1/20 0.36
PDE1A P54750 1/20 0.36
PDE1B Q01064 1/20 0.36
PDE1C Q14123 1/20 0.36
TLR8 Q9NR97 1/20 0.36
GRM5 P41594 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
PKM P14618 1/20 0.35
HPGD P15428 1/20 0.35
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
MEN1 O00255 1/20 0.34
CASP3 P42574 1/20 0.34
KMT2A Q03164 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
P2RX3 P56373 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24316545 0.93 CSF1R (0.43) CSF1RALKBH1PDE1APDE1BPDE1C
SCHEMBL24316661 0.90 CSF1R (0.52) CSF1RALKBH1PDE1APDE1BPDE1C
SCHEMBL24316548 0.87 CSF1R (0.47) CSF1RPDE1APDE1BPDE1CGRM5
SCHEMBL24316434 0.85 CSF1R (0.53) CSF1RALKBH1PDE1APDE1BPDE1C
SCHEMBL24316565 0.85 CSF1R (0.44) CSF1RALKBH1PDE1APDE1BPDE1C
SCHEMBL24316660 0.82 CSF1R (0.40) CSF1RALKBH1GRM5KDM4EALDH1A1
SCHEMBL24316588 0.81 CSF1R (0.44) CSF1R
SCHEMBL24316982 0.81 CSF1R (0.48) CSF1RALKBH1GRM5KDM4EALDH1A1
SCHEMBL24316659 0.80 ALKBH1 (0.40) CSF1RALKBH1PDE1APDE1BPDE1C
SCHEMBL24316428 0.79 ALKBH1 (0.39) CSF1RALKBH1PDE1APDE1BPDE1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022057895-A1 HETEROAROMATIC COMPOUNDS AND USES THEREOF HUTCHISON MEDIPHARMA LIMITED (CN) 2022-03-24 WO disclosed