Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323244 | 0.79 | ALDH1A1 (0.47) | POLBMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL3264491 | 0.76 | MTNR1A (0.71) | MTNR1AMTNR1BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL31483070 | 0.73 | MTNR1A (0.51) | MTNR1AMTNR1BPOLBMAPTSCN9A | |
| SCHEMBL24322995 | 0.72 | PPARD (0.58) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2187414 | 0.71 | MTNR1A (0.49) | MTNR1AMTNR1BPOLBMAPTSMN1; SMN2 | |
| SCHEMBL13272286 | 0.71 | HTR1B (0.61) | ALDH1A1SMN1; SMN2MRGPRX4 | |
| SCHEMBL30756752 | 0.71 | HTR1B (0.61) | ALDH1A1SMN1; SMN2MRGPRX4 | |
| SCHEMBL24324190 | 0.70 | ATF4 (0.52) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL21116381 | 0.69 | TP53 (0.45) | POLBMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL19577393 | 0.68 | ATF4 (0.56) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |