Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24325806 | 0.94 | GPR119 (0.34) | GPR119HTR6TRPV3USP30BCHE | |
| SCHEMBL24326684 | 0.91 | P2RX3 (0.33) | GPR119BRD4P2RX3TBK1 | |
| SCHEMBL24326679 | 0.85 | ALDH1A1 (0.41) | — | |
| SCHEMBL24326190 | 0.84 | TBK1 (0.42) | MEN1KMT2APARP1TBK1 | |
| SCHEMBL24326719 | 0.84 | GPR119 (0.34) | GPR119HTR6TRPV3USP30BCHE | |
| SCHEMBL24325795 | 0.83 | TBK1 (0.34) | MEN1KMT2ATBK1 | |
| SCHEMBL24326262 | 0.82 | ROCK2 (0.34) | TBK1 | |
| SCHEMBL24326178 | 0.80 | MMP3 (0.32) | TRPV3P2RX3 | |
| SCHEMBL24325763 | 0.80 | MMP3 (0.32) | TRPV3P2RX3 | |
| SCHEMBL24326398 | 0.79 | MEN1 (0.37) | TRPV3USP30MEN1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |