SCHEMBL24329124

SCHEMBL24329124

COc1cccc(C2CC(=C3C(=O)N(C)C(=O)N(C)C3=O)NN2C(C)=O)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
HTR2B P41595 1/20 0.35
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
MGLL Q99685 3/20 0.33
KDM4E B2RXH2 1/20 0.32
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.32
HTT P42858 1/20 0.32
YAP1 P46937 1/20 0.32
TEAD4 Q15561 1/20 0.32
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
GRM7 Q14831 1/20 0.32
FDFT1 P37268 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24328739 0.76 MAOA (0.40) MAOAMAOBKDM4EALDH1A1
SCHEMBL24329186 0.76 NT5E (0.37) KDM4EALDH1A1POLB
SCHEMBL24329174 0.76 HTR2A (0.34) HTR2AHTR2CHTR2BGAAALDH1A1
SCHEMBL24329753 0.74 NT5E (0.38) MAOBKDM4EHTTALDH1A1
SCHEMBL29564282 0.73 ACHE (0.41) MAOAMAOB
SCHEMBL24329162 0.73 MAOA (0.39) MAOAMAOBTP53ALDH1A1
SCHEMBL24329761 0.72 FFAR1 (0.38) ALDH1A1
SCHEMBL24329733 0.71 ACHE (0.44)
SCHEMBL24329668 0.68 RIPK1 (0.41) ALDH1A1
SCHEMBL24329750 0.65 KDM4E (0.39) KDM4EGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022080346-A1 NOVEL NITROGEN-CONTAINING CYCLIC COMPOUND AND APPLICATION THEREOF 国立大学法人佐賀大学 2022-04-21 WO disclosed
WO-2022080346-A1 NOVEL NITROGEN-CONTAINING CYCLIC COMPOUND AND APPLICATION THEREOF 国立大学法人佐賀大学 2022-04-21 WO disclosed