SCHEMBL24329174

SCHEMBL24329174

COc1cccc(C2CC(=C3C(=O)N(C)C(=O)N(C)C3=O)NN2)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.34
HTR2C P28335 2/20 0.34
HTR2B P41595 2/20 0.34
GRM7 Q14831 1/20 0.34
MAPT P10636 2/20 0.33
TSHR P16473 3/20 0.32
ADRA1B P35368 1/20 0.32
PRMT1 Q99873 1/20 0.32
CYP19A1 P11511 1/20 0.31
GAA P10253 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24329124 0.76 HTR2A (0.35) HTR2AHTR2CHTR2BGRM7GAA
SCHEMBL24329099 0.74 KMT2A (0.40) MAPTGAAALDH1A1
SCHEMBL29565262 0.73 ALDH1A1 (0.36) MAPTTSHRGAAALDH1A1
SCHEMBL24328743 0.73 BRD4 (0.42) MAPTTSHRALDH1A1
SCHEMBL29564756 0.71 TDP1 (0.32) TSHRGAA
SCHEMBL24329754 0.70 BRD4 (0.42) TSHR
SCHEMBL29564321 0.70 TP53 (0.34) MAPTGAAALDH1A1
SCHEMBL24329187 0.69 KCNH2 (0.38) MAPTCYP19A1ALDH1A1
SCHEMBL24328744 0.68 MEN1 (0.39) ALDH1A1
SCHEMBL5969365 0.64 TSHR (0.52) TSHRCYP19A1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022080346-A1 NOVEL NITROGEN-CONTAINING CYCLIC COMPOUND AND APPLICATION THEREOF 国立大学法人佐賀大学 2022-04-21 WO disclosed
WO-2022080346-A1 NOVEL NITROGEN-CONTAINING CYCLIC COMPOUND AND APPLICATION THEREOF 国立大学法人佐賀大学 2022-04-21 WO disclosed