SCHEMBL24329753

SCHEMBL24329753

CC(=O)N1NC(=C2C(=O)N(C)C(=O)N(C)C2=O)CC1c1ccc(F)cc1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.38
EGFR P00533 2/20 0.38
PTGS2 P35354 1/20 0.37
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAOB P27338 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
TERT O14746 3/20 0.33
CACNA1H O95180 1/20 0.33
HPGD P15428 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24329162 0.89 MAOA (0.39) EGFRPTGS2ALDH1A1MAOBCA12
SCHEMBL24328739 0.88 MAOA (0.40) EGFRPTGS2KDM4EALDH1A1MAOB
SCHEMBL24329186 0.88 NT5E (0.37) NT5EEGFRKDM4EALDH1A1
SCHEMBL24329761 0.83 FFAR1 (0.38) ALDH1A1CA12CA1CA2CA9
SCHEMBL24329733 0.82 ACHE (0.44) EGFRPTGS2SLC6A4SLC6A3
SCHEMBL24329668 0.76 RIPK1 (0.41) ALDH1A1
SCHEMBL24329750 0.75 KDM4E (0.39) KDM4EMAPTHTTTERT
SCHEMBL24329141 0.75 ALDH1A1 (0.38) KDM4EALDH1A1
SCHEMBL24329124 0.74 HTR2A (0.35) KDM4EALDH1A1HTTMAOB
SCHEMBL24329074 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022080346-A1 NOVEL NITROGEN-CONTAINING CYCLIC COMPOUND AND APPLICATION THEREOF 国立大学法人佐賀大学 2022-04-21 WO disclosed
WO-2022080346-A1 NOVEL NITROGEN-CONTAINING CYCLIC COMPOUND AND APPLICATION THEREOF 国立大学法人佐賀大学 2022-04-21 WO disclosed