Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27261377 | 0.81 | KDM4E (0.34) | C5AR1KDM4EHTR2C | |
| SCHEMBL18999659 | 0.74 | HTR2A (0.33) | KDM4EHTR2CHTR2AHTR2B | |
| SCHEMBL30826397 | 0.73 | ALDH1A1 (0.37) | C5AR1ALDH1A1KDM4EALOX15TSHR | |
| SCHEMBL29187830 | 0.73 | ALDH1A1 (0.37) | C5AR1ALDH1A1KDM4EALOX15TSHR | |
| SCHEMBL9914264 | 0.70 | FAAH (0.36) | C5AR1ALDH1A1ALOX15TSHRHTR2C | |
| SCHEMBL25844237 | 0.70 | MAOA (0.37) | TSHRHTR2CHTR2B | |
| SCHEMBL13180800 | 0.68 | ALOX12 (0.46) | HTR2CHTR2B | |
| SCHEMBL27010896 | 0.68 | HTR2A (0.37) | HTR2CHTR2AHTR2B | |
| SCHEMBL25820350 | 0.66 | GRM5 (0.40) | — | |
| SCHEMBL19121323 | 0.66 | KMT2A (0.50) | ALDH1A1KDM4EALOX15HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |