Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLLT1 | Q03111 | 4/20 | 0.49 |
| ▸ | MLLT3 | P42568 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24376314 | 0.82 | MLLT3 (0.64) | MLLT1MLLT3MAPK1NPC1RAB9A | |
| SCHEMBL24376430 | 0.80 | MLLT1 (0.71) | MLLT1MLLT3ROCK2PIM1GSK3B | |
| SCHEMBL21446983 | 0.79 | ROCK2 (0.59) | MLLT1MLLT3ROCK2PIM1GSK3B | |
| SCHEMBL24376316 | 0.76 | MLLT3 (0.49) | MLLT1MLLT3MAPK1NPC1RAB9A | |
| SCHEMBL6802996 | 0.73 | TP53 (0.68) | MLLT1ROCK2PIM1GSK3BNPC1 | |
| SCHEMBL926766 | 0.70 | NEU3 (0.53) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL19245571 | 0.70 | ROCK2 (0.57) | ROCK2PIM1GSK3BNPC1RAB9A | |
| SCHEMBL24376591 | 0.69 | MLLT3 (0.65) | MLLT1MLLT3MAPK1NPC1RAB9A | |
| SCHEMBL11275129 | 0.69 | CDH1 (0.61) | MAPK1NPC1RAB9AMAPTTP53 | |
| SCHEMBL2791692 | 0.69 | RAB9A (0.60) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |