Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30362812 | 1.00 | ESR1 (0.57) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL2717066 | 1.00 | ESR1 (0.57) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL18898251 | 1.00 | ESR1 (0.57) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL10074006 | 1.00 | ESR1 (0.57) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL21613691 | 1.00 | ESR1 (0.57) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL24103716 | 0.94 | ESR1 (0.64) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL30362800 | 0.94 | ESR1 (0.64) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL24103708 | 0.94 | ESR1 (0.64) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL244269 | 0.94 | ESR1 (0.64) | ESR1ESR2CYP3A4MAOAMAOB | |
| SCHEMBL24103714 | 0.93 | ESR2 (0.52) | ESR1ESR2CYP3A4MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140234295-A1 | ISOFLAVONOID COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER | MARSHALL EDWARDS, INC. (US) | 2014-08-21 | — | — | US | claimed |
| US-20130273177-A1 | ISOFLAVONOID COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | MARSHALL EDWARDS, INC. (US) | 2013-10-17 | — | — | US | claimed |
| EP-1809618-B1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | MARSHALL EDWARDS INC (US) | 2013-07-17 | — | — | EP | claimed |
| US-20120251630-A1 | REMISSION THERAPY OF CANCER WITH ISOFLAVONOIDS | MARSHALL EDWARDS, INC. (US) | 2012-10-04 | — | — | US | claimed |
| US-20120172424-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | MARSHALL EDWARDS, INC. (US) | 2012-07-05 | — | — | US | claimed |
| US-8163795-B2 | Chroman derivatives, medicaments and use in therapy | MARSHALL EDWARDS, INC. (US) | 2012-04-24 | — | — | US | claimed |
| US-20120039917-A1 | IMMUNOMODULATING ACTIVITIES | MARSHALL EDWARDS, INC. | 2012-02-16 | — | — | US | claimed |
| US-20120004296-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | MARSHALL EDWARDS, INC (US) | 2012-01-05 | — | — | US | claimed |
| US-8080675-B2 | Chroman derivatives, medicaments and use in therapy | MARSHALL EDWARDS, INC. (US) | 2011-12-20 | — | — | US | claimed |
| EP-1809618-A4 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | NOVOGEN RES PTY LTD (AU) | 2008-11-19 | — | — | EP | claimed |
| CN-101094844-A | Chroman derivatives, medicaments and use in therapy | NOVOGEN RES PTY LTD (AU) | 2007-12-26 | — | — | CN | claimed |
| EP-1809618-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | Novogen Research Pty Ltd (AU) | 2007-07-25 | — | — | EP | claimed |
| US-20060074126-A1 | Chroman derivatives, medicaments and use in therapy | NOVOGEN RESEARCH PTY LTD | 2006-04-06 | — | — | US | claimed |
| WO-2006032086-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | NOVOGEN RESEARCH PTY LTD (AU) | 2006-03-30 | — | — | WO | claimed |
| US-12414934-B2 | Combination therapies | Aardvark Therapeutics, Inc. (US) | 2025-09-16 | — | — | US | disclosed |
| US-12329739-B2 | Isoflavonoid compounds and methods for the treatment of cancer | Aardvark Therapeutic, Inc. (US) | 2025-06-17 | — | — | US | disclosed |
| US-12318364-B2 | Isoflavonoid compositions and methods for the treatment of cancer | Aardvark Therapeutics, Inc. (US) | 2025-06-03 | — | — | US | disclosed |
| EP-1809618-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | Novogen Research Pty Ltd (AU) | 2007-07-25 | — | — | EP | disclosed |
| US-20060074126-A1 | Chroman derivatives, medicaments and use in therapy | NOVOGEN RESEARCH PTY LTD | 2006-04-06 | — | — | US | disclosed |
| WO-2006032086-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | NOVOGEN RESEARCH PTY LTD (AU) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12414934-B2 | Combination therapies | PCK2, PDK1, PCK1 | ESR1 2467/4885ESR2 1403/4885CYP3A4 4003/4885 |
| US-20120251630-A1 | REMISSION THERAPY OF CANCER WITH ISOFLAVONOIDS | CYP19A1, HSD17B11, BRCA1 | ESR1 71/4885ESR2 9/4885CYP3A4 983/4885 |
| US-20120039917-A1 | IMMUNOMODULATING ACTIVITIES | CD4, NFATC1, HRH2 | ESR1 138/4885ESR2 43/4885CYP3A4 1056/4885 |
| US-20130273177-A1 | ISOFLAVONOID COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | BAX, CASP3, SI | ESR1 176/4885ESR2 154/4885CYP3A4 683/4885 |
| US-12318364-B2 | Isoflavonoid compositions and methods for the treatment of cancer | BAX, CASP3, SI | ESR1 176/4885ESR2 154/4885CYP3A4 683/4885 |
| US-20140234295-A1 | ISOFLAVONOID COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER | BAX, CASP3, API5 | ESR1 57/4885ESR2 22/4885CYP3A4 2283/4885 |
| US-20120172424-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | CDYL, XPA, TP53 | ESR1 1699/4885ESR2 1586/4885CYP3A4 1392/4885 |
| US-20060074126-A1 | Chroman derivatives, medicaments and use in therapy | CDYL, XPA, TP53 | ESR1 1699/4885ESR2 1586/4885CYP3A4 1392/4885 |
| US-20120004296-A1 | CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY | CDYL, XPA, TP53 | ESR1 1699/4885ESR2 1586/4885CYP3A4 1392/4885 |
| US-12329739-B2 | Isoflavonoid compounds and methods for the treatment of cancer | BAX, CASP3, API5 | ESR1 57/4885ESR2 22/4885CYP3A4 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.