Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089375 | 0.98 | DNMT1 (0.58) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL3080269 | 0.98 | DNMT1 (0.58) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL3086724 | 0.93 | DNMT1 (0.59) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL3079234 | 0.93 | DNMT1 (0.59) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL1984728 | 0.88 | DNMT1 (0.75) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL2445932 | 0.88 | DNMT1 (0.75) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL3081901 | 0.88 | DNMT1 (0.75) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL2443777 | 0.84 | DNMT1 (0.73) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL19244073 | 0.84 | DNMT1 (0.73) | DNMT1KMT2ACYP2C19DNMT3BPKM | |
| SCHEMBL3087159 | 0.83 | DNMT1 (0.56) | DNMT1KMT2ACYP2C19DNMT3BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912185-B2 | Use of glutaric acid derivatives or the pharmaceutically acceptable salts thereof as anti-arrhythmic agents | Obschestvo S Ogranichennoi Otvetstvennostyu “Pharmenterprises” (RU) | 2014-12-16 | — | — | US | disclosed |
| US-20130324540-A1 | USE OF GLUTARIC ACID DERIVATIVES OR THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS ANTI-ARRHYTHMIC AGENTS | Obschestvo Ogranichennoi Otvetstvennostyu "Pharmenterprises" (RU) | 2013-12-05 | — | — | US | disclosed |
| US-20110224213-A1 | Use of Glutaric Acid Derivatives or the Pharmaceutically Acceptable Salts Thereof as Anti-Arrhythmic Agents | OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "PHARMENTERPRISES" (RU) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324540-A1 | USE OF GLUTARIC ACID DERIVATIVES OR THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS ANTI-ARRHYTHMIC AGENTS | GCDH, ALDH5A1, GLS2 | DNMT1 4646/4885KMT2A 2434/4885CYP2C19 536/4885 |
| US-20110224213-A1 | Use of Glutaric Acid Derivatives or the Pharmaceutically Acceptable Salts Thereof as Anti-Arrhythmic Agents | GCDH, ALDH5A1, GLS2 | DNMT1 4646/4885KMT2A 2434/4885CYP2C19 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.