Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28455365 | 0.86 | CYP3A4 (0.42) | CRHR1ALDH1A1HSP90AA1ALPLL3MBTL1 | |
| SCHEMBL29606642 | 0.86 | CYP3A4 (0.42) | CRHR1ALDH1A1HSP90AA1ALPLL3MBTL1 | |
| SCHEMBL29606632 | 0.85 | HPGD (0.40) | CRHR1ALDH1A1HSP90AA1HSP90AB1ALPL | |
| SCHEMBL24397796 | 0.82 | HPGD (0.48) | ALDH1A1ALPLMAPTKEAP1SLC6A3 | |
| SCHEMBL30704844 | 0.81 | ALDH1A1 (0.46) | CRHR1ALDH1A1ALPLL3MBTL1CYP3A4 | |
| SCHEMBL11689552 | 0.78 | ALDH1A1 (0.51) | CRHR1ALDH1A1HSP90AA1HSP90AB1ALPL | |
| SCHEMBL28898749 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MAPTCYP3A4NPC1RAB9A | |
| SCHEMBL29606902 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MAPTCYP3A4NPC1RAB9A | |
| SCHEMBL8574746 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HSP90AA1HSP90AB1ALPLMAPT | |
| SCHEMBL28794509 | 0.76 | AKR1C4 (0.55) | ALDH1A1MAPTCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285508-A | Preparation method of pyridyl pyrazole amide compound and intermediate thereof | 湖南化工研究院有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-114516855-A | Preparation of pyridylpyrazole amide compounds and intermediates therefor | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | claimed |
| CN-114516854-A | Preparation method of 1-pyridyl pyrazole amide compound and intermediate thereof | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | claimed |
| CN-117285508-A | Preparation method of pyridyl pyrazole amide compound and intermediate thereof | 湖南化工研究院有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-114516855-A | Preparation of pyridylpyrazole amide compounds and intermediates therefor | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-114516854-A | Preparation method of 1-pyridyl pyrazole amide compound and intermediate thereof | 湖南化工研究院有限公司 | 2022-05-20 | — | — | CN | disclosed |
| US-20220132846-A1 | 1-PYRIDYL-PYRAZOLYL AMIDE COMPOUNDS AND PREPARATION AND USES THEREOF | HUNAN RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2022-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220132846-A1 | 1-PYRIDYL-PYRAZOLYL AMIDE COMPOUNDS AND PREPARATION AND USES THEREOF | ACHE, PDHB, PDXK | CRHR1 4546/4885ALDH1A1 419/4885HSP90AA1 3652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.