Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 16/20 | 1.00 |
| ▸ | MTHFD1 | P11586 | 5/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30825595 | 1.00 | MTHFD2 (1.00) | MTHFD2MTHFD1DRD4NQO1 | |
| SCHEMBL5370174 | 0.85 | MTHFD2 (0.73) | MTHFD2MTHFD1DRD4 | |
| SCHEMBL10811259 | 0.71 | MTHFD2 (0.55) | MTHFD2DRD4 | |
| SCHEMBL11844405 | 0.69 | MTHFD2 (0.88) | MTHFD2 | |
| SCHEMBL5507692 | 0.69 | MTHFD2 (0.52) | MTHFD2DRD4 | |
| SCHEMBL2987838 | 0.67 | MTHFD2 (0.54) | MTHFD2 | |
| SCHEMBL7562741 | 0.67 | KDM4E (0.60) | — | |
| SCHEMBL11762718 | 0.67 | MAOA (0.60) | MTHFD2 | |
| SCHEMBL19965770 | 0.67 | SIGMAR1 (0.56) | MTHFD2 | |
| SCHEMBL3079170 | 0.66 | MAPT (0.71) | MTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104010-A1 | COMBINATIONS OF METHYLENE TETRAHYDROFOLATE DEHYDROGENASE 2 (MTHFD2) INHIBITORS AND FOLATE-DEPLETING AGENTS AND METHODS USING SAME | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-05-19 | — | — | WO | disclosed |