Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29685934 | 1.00 | CASP1 (0.36) | CASP1TRPV3ALDH1A1KDM4ENPC1 | |
| SCHEMBL30803836 | 0.79 | SLC6A9 (0.41) | — | |
| SCHEMBL29686000 | 0.75 | LMNA (0.40) | NPC1SMN1; SMN2LMNAKMT2AAAK1 | |
| SCHEMBL24468312 | 0.75 | LMNA (0.40) | NPC1SMN1; SMN2LMNAKMT2AAAK1 | |
| SCHEMBL1549826 | 0.73 | PAX8 (0.46) | ALDH1A1KDM4ENPC1MAPTHPGD | |
| SCHEMBL2609362 | 0.73 | MAOB (0.43) | CASP1TRPV3MAOB | |
| SCHEMBL29106458 | 0.72 | CASP1 (0.45) | CASP1TRPV3ALDH1A1L3MBTL1MAOB | |
| SCHEMBL5937941 | 0.68 | ALDH1A1 (0.39) | TRPV3ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL24468310 | 0.68 | KIF11 (0.41) | CASP1TRPV3MAOBLMNAADORA3 | |
| SCHEMBL29686526 | 0.68 | KIF11 (0.41) | CASP1TRPV3MAOBLMNAADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |