Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17824919 | 0.76 | PRMT5 (0.50) | CNR2CNR1SLC6A4MAPK1 | |
| SCHEMBL24469149 | 0.76 | CNR1 (0.33) | CNR2CNR1IRAK4MAPTLMNA | |
| SCHEMBL24469167 | 0.75 | P2RX3 (0.41) | — | |
| SCHEMBL2462679 | 0.70 | ALOX15 (0.42) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24469239 | 0.67 | POLB (0.36) | SLC6A4IRAK4 | |
| SCHEMBL28850191 | 0.66 | SLC6A4 (0.34) | SLC6A4 | |
| SCHEMBL4764975 | 0.65 | PTGES (0.33) | CNR2CNR1MAPK1SLC2A1SLC2A2 | |
| SCHEMBL26732579 | 0.65 | ALOX15 (0.38) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30451573 | 0.65 | ALOX15 (0.38) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17825029 | 0.65 | PRMT5 (0.55) | SLC6A4LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12534455-B2 | Phthalazine derivatives as P2X3 inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2026-01-27 | — | — | US | disclosed |
| EP-4251273-B1 | PHTHALAZINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARM SPA (IT) | 2025-03-12 | — | — | EP | disclosed |
| US-20240002371-A1 | PHTHALAZINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-01-04 | — | — | US | disclosed |
| CN-116745284-A | Phthalazine derivatives as P2X3 inhibitors | 奇斯药制品公司 | 2023-09-12 | — | — | CN | disclosed |
| WO-2022112493-A1 | PHTHALAZINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12534455-B2 | Phthalazine derivatives as P2X3 inhibitors | P2RX3, P2RX5, P2RX7 | CNR2 78/4885CNR1 75/4885SLC6A4 1428/4885 |
| US-20240002371-A1 | PHTHALAZINE DERIVATIVES AS P2X3 INHIBITORS | P2RX3, P2RX5, P2RX2 | CNR2 191/4885CNR1 213/4885SLC6A4 3321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.