Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24469661 | 0.73 | ACVRL1 (0.42) | TSHRNNMTHSD17B10SIRT6 | |
| SCHEMBL21225333 | 0.71 | TSHR (0.41) | TSHRHSD17B10PARP1RORCALDH1A1 | |
| SCHEMBL29520278 | 0.71 | TSHR (0.41) | TSHRHSD17B10PARP1RORCALDH1A1 | |
| SCHEMBL28763414 | 0.68 | POLB (0.38) | HSD17B10PARP1KDM4EALDH1A1HPGD | |
| SCHEMBL24469604 | 0.68 | PARP1 (0.42) | NNMTPARP1KDM4EL3MBTL1 | |
| SCHEMBL17371696 | 0.68 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL6282473 | 0.66 | NNMT (0.51) | TSHRNNMTPARP1LMNA | |
| SCHEMBL30427718 | 0.66 | NNMT (0.51) | TSHRNNMTPARP1LMNA | |
| SCHEMBL7425664 | 0.64 | SIRT6 (0.38) | TSHRNNMTHSD17B10SIRT6ALDH1A1 | |
| SCHEMBL1703067 | 0.63 | ICAM1 (0.47) | TSHRNNMTHSD17B10SIRT6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251149-A1 | MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022115301-A1 | MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022115301-A1 | MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-06-02 | — | — | WO | disclosed |