Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22830598 | 0.91 | GPR119 (0.37) | P2RX3HDAC1HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL22845221 | 0.90 | GCGR (0.40) | P2RX3HDAC1HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL24469917 | 0.88 | HDAC1 (0.36) | P2RX3HDAC1HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL24470081 | 0.86 | GPR119 (0.36) | P2RX3HDAC1HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL24469871 | 0.86 | ADAM17 (0.34) | HDAC1HDAC6SMN1; SMN2MEN1CYP2C19 | |
| SCHEMBL24469814 | 0.85 | P2RX3 (0.40) | P2RX3HDAC1HDAC6LMNAUSP30 | |
| SCHEMBL24469994 | 0.84 | LMNA (0.34) | HDAC1HDAC6LMNATDP1USP30 | |
| SCHEMBL24470065 | 0.84 | P2RX3 (0.41) | P2RX3TDP1TP53GPR119MAPT | |
| SCHEMBL22845199 | 0.84 | LMNA (0.37) | HDAC1HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24469883 | 0.82 | MGLL (0.36) | HDAC1HDAC6SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820773-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| US-11820773-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| US-20220169650-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169650-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | P2RX3 3237/4885HDAC1 47/4885HDAC6 12/4885 |
| US-11820773-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | P2RX3 3237/4885HDAC1 47/4885HDAC6 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.