Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.64 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.58 |
| ▸ | GPX4 | P36969 | 6/20 | 0.58 |
| ▸ | STS | P08842 | 1/20 | 0.55 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.52 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5688541 | 0.95 | CACNA2D1 (0.60) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL14051945 | 0.87 | GPX4 (0.54) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL15101001 | 0.86 | CNR1 (0.49) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL31023808 | 0.86 | MGLL (0.55) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL4013471 | 0.86 | KMT2A (0.67) | MGLLMEN1KMT2ACYP3A4CACNA2D1 | |
| SCHEMBL12371643 | 0.85 | MEN1 (0.56) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL31023690 | 0.85 | ALDH1A1 (0.58) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL19327134 | 0.84 | CYP3A4 (0.53) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL25083480 | 0.83 | MEN1 (0.54) | MGLLABHD6MEN1KMT2ACYP3A4 | |
| SCHEMBL14593305 | 0.83 | MEN1 (0.54) | MGLLABHD6MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093630-B2 | Pyrazole compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-10-09 | — | — | US | disclosed |
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-07-06 | — | — | US | disclosed |
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-07-06 | — | — | US | disclosed |
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-07-06 | — | — | US | disclosed |
| WO-2015179559-A2 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2015-11-26 | — | — | WO | disclosed |
| WO-2015179559-A2 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, FAAH, FAAH2 | MGLL 7/4885ABHD6 1/4885MEN1 3710/4885 |
| US-10093630-B2 | Pyrazole compounds and methods of making and using same | ABHD6, FAAH, FAAH2 | MGLL 7/4885ABHD6 1/4885MEN1 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.