Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.72 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | PRKACG | P22612 | 1/20 | 0.31 |
| ▸ | PRKACB | P22694 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.31 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.31 |
| ▸ | ACAD10 | Q6JQN1 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26167 | 0.85 | — | — | |
| Uracil SCHEMBL27680066 | 0.80 | CRBN (0.68) | MMP2CRBNTP53ALDH1A1ROCK1 | |
| Uracil SCHEMBL29096415 | 0.77 | CRBN (0.77) | MMP2CRBNTP53TYMPGSK3B | |
| Uracil SCHEMBL23271222 | 0.77 | MMP2 (0.82) | MMP2CRBNTP53TYMPGSK3B | |
| Uracil SCHEMBL9385917 | 0.72 | CRBN (0.77) | MMP2CRBNTP53TYMPGSK3B | |
| Thymine SCHEMBL5007601 | 0.68 | ATAD2 (0.68) | MMP2CRBNTP53ALDH1A1TYMP | |
| Piperidine SCHEMBL17924578 | 0.65 | ALDH1A1 (0.56) | CRBNALDH1A1TYMP | |
| Uracil SCHEMBL11607890 | 0.63 | — | — | |
| Uracil SCHEMBL8235 | 0.63 | — | — | |
| Uracil SCHEMBL8767625 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366700-A8 | Pyrrolidine-thioxopyrimidinone/thiohydantoin organocatolysts | National and Kapodistrian Universty of Athens (GR) | 2011-11-09 | — | — | EP | disclosed |
| EP-2366700-A1 | Pyrrolidine-thioxopyrimidinone/thiohydantoin organocatolysts | National and Kapodistrian Universty of Athens (GR) | 2011-09-21 | — | — | EP | disclosed |