Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | OGT | O15294 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19139451 | 0.92 | NOS1 (0.46) | MAPTNOS1SMYD3GRIN2DGRIN3B | |
| SCHEMBL26107118 | 0.74 | MAOA (0.45) | MAPTALPLKDM4EALDH1A1MAOB | |
| SCHEMBL2895090 | 0.74 | SLC6A4 (0.56) | NOS1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2895084 | 0.74 | SLC6A4 (0.56) | NOS1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2895085 | 0.74 | SLC6A4 (0.56) | NOS1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL12510619 | 0.74 | HSD11B1 (0.42) | DHFR | |
| SCHEMBL3500438 | 0.73 | TNK2 (0.44) | KDM4EALDH1A1SMN1; SMN2DHFR | |
| SCHEMBL17260660 | 0.73 | NFE2L2 (0.48) | MAPTPDE3BPDE3AKDM1AENPP2 | |
| SCHEMBL14478988 | 0.72 | MAOA (0.64) | KDM4EALDH1A1MAOBMAOA | |
| SCHEMBL16963882 | 0.72 | NOS1 (0.59) | NOS1CREBBPALPLPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117820253-A | 3, 6-disubstituted benzothiazole compound and synthesis and application thereof | 西北农林科技大学 | 2024-04-05 | — | — | CN | disclosed |
| US-11584717-B2 | MIF modulators | YALE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20190270706-A1 | MIF MODULATORS | UNIV YALE (US) | 2019-09-05 | — | — | US | disclosed |
| US-10202343-B2 | MIF modulators | YALE UNIVERSITY (US) | 2019-02-12 | — | — | US | disclosed |
| US-10202343-B2 | MIF modulators | YALE UNIVERSITY (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180162813-A1 | MIF MODULATORS | YALE UNIVERSITY | 2018-06-14 | — | — | US | disclosed |
| US-20180162813-A1 | MIF MODULATORS | YALE UNIVERSITY | 2018-06-14 | — | — | US | disclosed |
| US-9643922-B2 | MIF modulators | YALE UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643922-B2 | MIF modulators | YALE UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-20120004261-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004261-A1 | MIF MODULATORS | YALE UNIVERSITY (US) | 2012-01-05 | — | — | US | disclosed |
| WO-2011140202-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140202-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2011-11-10 | — | — | WO | disclosed |
| EP-2326631-A2 | MIF MODULATORS | Yale University (US) | 2011-06-01 | — | — | EP | disclosed |
| US-20100267714-A1 | MIF MODULATORS | YALE UNIVERSITY | 2010-10-21 | — | — | US | disclosed |
| US-20100267714-A1 | MIF MODULATORS | YALE UNIVERSITY | 2010-10-21 | — | — | US | disclosed |
| US-20100267714-A1 | MIF MODULATORS | YALE UNIVERSITY | 2010-10-21 | — | — | US | disclosed |
| WO-2010021693-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010021693-A2 | MIF MODULATORS | YALE UNIVERSITY (US) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584717-B2 | MIF modulators | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
| US-20200377457-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
| US-20180162813-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
| US-20120004261-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
| US-20100267714-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
| US-10202343-B2 | MIF modulators | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
| US-20190270706-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | MAPT 3356/4885NOS1 492/4885SMYD3 3536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.