Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24616779 | 0.80 | HCAR2 (0.37) | HCAR2 | |
| SCHEMBL24616777 | 0.79 | HCAR2 (0.33) | HCAR2ALDH1A1 | |
| SCHEMBL24616741 | 0.77 | HCAR2 (0.32) | HCAR2 | |
| SCHEMBL29398715 | 0.75 | FFAR4 (0.36) | HCAR2THRBGAAHDAC3HDAC1 | |
| SCHEMBL24616769 | 0.75 | FFAR4 (0.36) | HCAR2THRBGAAHDAC3HDAC1 | |
| SCHEMBL24616796 | 0.75 | AKR1C3 (0.31) | HCAR2 | |
| SCHEMBL24616690 | 0.74 | ALDH1A1 (0.38) | HCAR2HDAC1ALDH1A1MEN1KMT2A | |
| SCHEMBL24616793 | 0.74 | HSD11B1 (0.38) | HCAR2THRBALDH1A1MEN1KMT2A | |
| SCHEMBL24616798 | 0.72 | HCAR2 (0.36) | HCAR2ALDH1A1 | |
| SCHEMBL24616783 | 0.72 | KMT2A (0.48) | THRBGAAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022038365-A9 | FUMARATE DERIVATIVES AND THEIR MEDICAL USE | SITRYX THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | disclosed |