Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.47 |
| ▸ | CHRM4 known ✓ | P08173 | 5/20 | 0.47 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.44 |
| ▸ | CHRM5 known ✓ | P08912 | 4/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1597440 | 0.98 | THRB (0.53) | THRBTSHRCHRM1CHRM3CHRM4 | |
| Hydrochloric Acid SCHEMBL475669 | 0.98 | THRB (0.53) | THRBTSHRCHRM1CHRM3CHRM4 | |
| Sulfuric Acid SCHEMBL1683534 | 0.91 | THRB (0.47) | THRBTSHRCHRM1CHRM3CHRM4 | |
| Hydrochloric Acid SCHEMBL5455297 | 0.87 | TSHR (0.58) | THRBTSHRCHRM1CHRM3CHRM4 | |
| SCHEMBL27862861 | 0.87 | TSHR (0.58) | THRBTSHRCHRM1CHRM3CHRM4 | |
| Hydrochloric Acid SCHEMBL14335996 | 0.87 | TSHR (0.45) | THRBTSHRCHRM1CHRM3CHRM4 | |
| SCHEMBL630863 | 0.86 | THRB (0.42) | THRBTSHRCHRM1CHRM3CHRM4 | |
| Bromide SCHEMBL4367449 | 0.85 | THRB (0.52) | THRBTSHRCHRM1CHRM3CHRM4 | |
| SCHEMBL344298 | 0.85 | TSHR (0.55) | THRBTSHRCHRM1CHRM3CHRM4 | |
| Hydrochloric Acid SCHEMBL27676698 | 0.84 | TSHR (0.64) | THRBTSHRCHRM1CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197740-A1 | METHOTREXATE TREATMENT METHODS | ALDEYRA THERAPEUTICS, INC. | 2024-06-20 | — | — | US | disclosed |
| WO-2024129979-A1 | METHOTREXATE TREATMENT METHODS | ALDEYRA THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |
| US-11998767-B2 | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines | GOJO INDUSTRIES, INC. (US) | 2024-06-04 | — | — | US | disclosed |
| US-11911385-B1 | Methotrexate treatment methods | ALDEYRA THERAPEUTICS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| EP-3116986-B1 | HAND SANITIZERS WITH IMPROVED AESTHETICS AND SKIN-CONDITIONING TO ENCOURAGE COMPLIANCE WITH HAND HYGIENE GUIDELINES | GOJO IND INC (US) | 2023-07-05 | — | — | EP | disclosed |
| US-20220133697-A1 | INJECTABLE FORMULATIONS | ALDEYRA THERAPEUTICS, INC. | 2022-05-05 | — | — | US | disclosed |
| US-20210393993-A1 | HAND SANITIZERS WITH IMPROVED AESTHETICS AND SKIN-CONDITIONING TO ENCOURAGE COMPLIANCE WITH HAND HYGIENE GUIDELINES | SILVER POINT FINANCE, LLC, AS COLLATERAL AGENT | 2021-12-23 | — | — | US | disclosed |
| EP-3890732-A1 | INJECTABLE FORMULATIONS | Aldeyra Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| US-11135456-B2 | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines | GOJO INDUSTRIES, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210060110-A1 | ANTISEPTIC COMPOSITONS AND METHODS OF USE | 3M INNOVATIVE PROPERTIES COMPANY | 2021-03-04 | — | — | US | disclosed |
| US-20060052452-A1 | Phenolic antiseptic compositions and methods of use | 3M INNOVATIVE PROPERTIES COMPANY | 2006-03-09 | — | — | US | disclosed |
| US-20050089539-A1 | Antimicrobial compositions and methods | 3M INNOVATIVE PROPERTIES COMPANY | 2005-04-28 | — | — | US | disclosed |
| US-20050058673-A1 | Antimicrobial compositions and methods | 3M INNOVATIVE PROPERTIES COMPANY | 2005-03-17 | — | — | US | disclosed |
| US-20030215418-A1 | Hydroalcoholic compositions thickened using polymers | 3M INNOVATIVE PROPERTIES COMPANY | 2003-11-20 | — | — | US | disclosed |
| EP-0963158-B1 | HYDROALCOHOLIC COMPOSITIONS THICKENED USING POLYMERS | MINNESOTA MINING & MFG (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6582711-B1 | An antimicrobial hydroalcoholic composition comprising hydroalcoholic solvent system comprising a lower alcohol and water in a weight ratio of at least about 50:50; a thickener system comprising at least one cationic or nonionic polymeric | 3M INNOVATIVE PROPERTIES COMPANY | 2003-06-24 | — | — | US | disclosed |
| US-6482562-B2 | DISSOLVING POLYMER IN ORGANIC SOLVENT, DISPERSING IN A STABILIZER AND HOMOGENIZING, ADDING A FLOCCULATING AGENT OF A CATIONIC SURFACTANT THAT IS AN AMMONIUM SALT, EVAPORATING THE ORGANIC SOLVENT, WASHING AND DRYING | EASTMAN KODAK COMPANY | 2002-11-19 | — | — | US | disclosed |
| US-20020068233-A1 | Toner particles of controlled morphology | EASTMAN KODAK COMPANY | 2002-06-06 | — | — | US | disclosed |
| EP-0963158-A1 | HYDROALCOHOLIC COMPOSITIONS THICKENED USING POLYMERS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-12-15 | — | — | EP | disclosed |
| WO-1998030095-A1 | HYDROALCOHOLIC COMPOSITIONS THICKENED USING POLYMERS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210060110-A1 | ANTISEPTIC COMPOSITONS AND METHODS OF USE | C9, C1S, FABP2 | CHRM1 957/4885CHRM3 623/4885CHRM4 1311/4885 |
| US-20210393993-A1 | HAND SANITIZERS WITH IMPROVED AESTHETICS AND SKIN-CONDITIONING TO ENCOURAGE COMPLIANCE WITH HAND HYGIENE GUIDELINES | CUTA, HAAO, HRH1 | CHRM1 3964/4885CHRM3 4817/4885CHRM4 4833/4885 |
| US-20220133697-A1 | INJECTABLE FORMULATIONS | ALDH2, CLN6, ALDH1A1 | CHRM1 2282/4885CHRM3 1863/4885CHRM4 2056/4885 |
| US-20060052452-A1 | Phenolic antiseptic compositions and methods of use | FABP2, EBP, LCT | CHRM1 3333/4885CHRM3 1981/4885CHRM4 2848/4885 |
| US-20050089539-A1 | Antimicrobial compositions and methods | FABP2, CUTA, LIPA | CHRM1 4360/4885CHRM3 3196/4885CHRM4 3989/4885 |
| US-20050058673-A1 | Antimicrobial compositions and methods | FABP2, CUTA, LIPA | CHRM1 4291/4885CHRM3 3000/4885CHRM4 3897/4885 |
| US-11135456-B2 | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines | CUTA, HAAO, HRH1 | CHRM1 3964/4885CHRM3 4817/4885CHRM4 4833/4885 |
| US-11998767-B2 | Hand sanitizers with improved aesthetics and skin-conditioning to encourage compliance with hand hygiene guidelines | CUTA, HAAO, HRH1 | CHRM1 3964/4885CHRM3 4817/4885CHRM4 4833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.