Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH3 | Q96Q83 | 4/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462203 | 0.88 | ALKBH3 (0.44) | ALKBH3CCR2PTGS1PTGS2ALDH1A1 | |
| SCHEMBL2464343 | 0.88 | ALKBH3 (0.40) | ALKBH3CCR2ALDH1A1HPGDTYMS | |
| SCHEMBL2425276 | 0.88 | KDM4E (0.46) | ALKBH3ALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL2462018 | 0.86 | PDE10A (0.40) | ALKBH3ALDH1A1HPGDSMN1; SMN2TYMS | |
| SCHEMBL2454543 | 0.86 | ADCY10 (0.44) | ALKBH3CCR2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12325085 | 0.86 | NPSR1 (0.48) | ALKBH3CCR2PTGS1PTGS2ALDH1A1 | |
| SCHEMBL2457171 | 0.82 | ALKBH3 (0.48) | ALKBH3CCR2ALDH1A1HPGDTYMS | |
| SCHEMBL12324669 | 0.81 | ALKBH3 (0.36) | ALKBH3ALDH1A1HPGDKDM4E | |
| SCHEMBL12324675 | 0.81 | KDM4E (0.40) | ALDH1A1HPGDSMN1; SMN2KDM4EADCY10 | |
| SCHEMBL2463316 | 0.81 | THRB (0.46) | ALKBH3CCR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |