Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH3 | Q96Q83 | 5/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | TYMP | P19971 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462220 | 0.88 | ALKBH3 (0.46) | ALKBH3CCR2TYMSTYMPKDM4E | |
| SCHEMBL2462203 | 0.88 | ALKBH3 (0.44) | ALKBH3CCR2TYMSPDE3BPDE3A | |
| SCHEMBL2425276 | 0.88 | KDM4E (0.46) | ALKBH3KDM4EHPGDALDH1A1 | |
| SCHEMBL2462018 | 0.86 | PDE10A (0.40) | ALKBH3TYMSPDE3BPDE3AKDM4E | |
| SCHEMBL2456787 | 0.86 | CCR2 (0.43) | ALKBH3CCR2POLBKDM4EHPGD | |
| SCHEMBL12325085 | 0.86 | NPSR1 (0.48) | ALKBH3CCR2TYMSTYMPKDM4E | |
| SCHEMBL2457171 | 0.82 | ALKBH3 (0.48) | ALKBH3CCR2POLBTYMSTYMP | |
| SCHEMBL2461969 | 0.80 | PNP (0.39) | KDM4EHPGDALDH1A1CCNE2CCNE1 | |
| SCHEMBL2459259 | 0.79 | CCR2 (0.51) | ALKBH3CCR2 | |
| SCHEMBL2454543 | 0.79 | ADCY10 (0.44) | ALKBH3CCR2PDE3BPDE3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |