Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY10 | Q96PN6 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463316 | 0.89 | THRB (0.46) | CCR2ENPP1KDM4EALDH1A1HTR6 | |
| SCHEMBL2456787 | 0.87 | CCR2 (0.43) | CCR2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2459259 | 0.87 | CCR2 (0.51) | ADCY10CCR2ALKBH3 | |
| SCHEMBL2462220 | 0.86 | ALKBH3 (0.46) | ADCY10CCR2KDM4EALDH1A1HPGD | |
| SCHEMBL12324736 | 0.86 | CCR2 (0.46) | CCR2ALKBH3 | |
| SCHEMBL2425276 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL12324673 | 0.85 | IDH1 (0.47) | ADCY10CCR2ENPP1HTR6IDH1 | |
| SCHEMBL2459014 | 0.82 | GPR52 (0.41) | ALKBH3 | |
| SCHEMBL2461969 | 0.81 | PNP (0.39) | KDM4EALDH1A1HPGD | |
| SCHEMBL2457171 | 0.81 | ALKBH3 (0.48) | CCR2ALDH1A1HPGDHTR6ALKBH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |