Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.42 |
| ▸ | ILK | Q13418 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462304 | 0.87 | ACVR1 (0.44) | ACVR1PIM1PIM3PIM2ROCK2 | |
| SCHEMBL2455990 | 0.75 | ALDH1A1 (0.36) | — | |
| SCHEMBL2457178 | 0.74 | DYRK1A (0.54) | ACVR1PIM1PIM3PIM2ROCK2 | |
| SCHEMBL2461256 | 0.72 | AKT2 (0.43) | ACVR1PIM1PIM3PIM2ROCK2 | |
| SCHEMBL19031537 | 0.72 | ALKBH5 (0.62) | — | |
| SCHEMBL19302828 | 0.72 | ROCK2 (0.56) | PIM1PIM3PIM2ROCK2ILK | |
| SCHEMBL2463712 | 0.71 | NOTUM (0.47) | PIM1 | |
| SCHEMBL2458543 | 0.70 | CYP11B1 (0.47) | — | |
| SCHEMBL16432987 | 0.70 | AKT2 (0.76) | ACVR1PIM1PIM3PIM2ROCK2 | |
| SCHEMBL15689115 | 0.70 | AKT2 (0.76) | ACVR1PIM1PIM3PIM2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
| WO-2010068287-A2 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | ACVR1 277/4885PIM1 1476/4885PIM3 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.