Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29960499 | 1.00 | HPGD (0.56) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL9587541 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1HTTMAPT | |
| SCHEMBL1836106 | 0.87 | L3MBTL1 (0.51) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL14559775 | 0.84 | ALDH1A1 (0.54) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL2463257 | 0.84 | HPGD (0.46) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL8173356 | 0.84 | ALDH1A1 (0.46) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL7209100 | 0.84 | HPGD (0.46) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL646870 | 0.83 | ALDH1A1 (0.50) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL29729975 | 0.83 | ALDH1A1 (0.50) | HPGDALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL194382 | 0.82 | NR1H4 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022218-B2 | Hypogonadism; N-{3-[2-Bromo-4-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-6-ethoxy-phenoxymethyl]-phenyl}-3,4,5-trimethoxy-benzamide; low molecular weight hormone mimetics; selective Follicle Stimulating Hormone receptor agonists | N.V. ORGANON (NL) | 2011-09-20 | — | — | US | disclosed |
| US-20080275042-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline Derivatives for the Treatment of Infertility | N.V. ORGANON (NL) | 2008-11-06 | — | — | US | disclosed |
| EP-1881830-B1 | 4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES THE TREATMENT OF INFERTILITY | ORGANON NV (NL) | 2008-10-08 | — | — | EP | disclosed |
| EP-1881830-A1 | 4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES THE TREATMENT OF INFERTILITY | N.V. Organon (NL) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006117368-A1 | 4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES THE TREATMENT OF INFERTILITY | N.V. ORGANON (NL) | 2006-11-09 | — | — | WO | disclosed |
| US-4831041-A | ANTIULCER AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-05-16 | — | — | US | disclosed |
| EP-0268989-A1 | Imidazopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275042-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline Derivatives for the Treatment of Infertility | CATSPER1, ABCB11, ACR | HPGD 3408/4885ALDH1A1 79/4885NPC1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.