Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 2/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447552 | 0.81 | STK17B (0.43) | LMNASMN1; SMN2CYP1A2PDE4ACYP2C19 | |
| SCHEMBL3644211 | 0.79 | XDH (0.41) | SMN1; SMN2PIN1ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL12985024 | 0.78 | KMT2A (0.46) | LMNASMN1; SMN2CYP1A2PDE4ACYP2C19 | |
| SCHEMBL7177583 | 0.78 | ALDH1A1 (0.50) | LMNASMN1; SMN2CYP1A2PDE4ACYP2C19 | |
| SCHEMBL30989056 | 0.75 | ALDH1A1 (0.35) | PIN1ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL21287682 | 0.75 | ALDH1A1 (0.35) | PIN1ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL20172034 | 0.74 | PIN1 (0.33) | PIN1ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL15584954 | 0.74 | TDP1 (0.39) | LMNASMN1; SMN2GLP1RHTTNPC1 | |
| SCHEMBL3646724 | 0.74 | LMNA (0.39) | LMNAGLP1RSTK17BSTK17APIN1 | |
| SCHEMBL15584140 | 0.71 | STK17B (0.37) | POLBHTTSTK17BSTK17ALATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
| WO-2009124965-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | PRKCZ, PRKCQ, PRKCD | LMNA 2531/4885SMN1; SMN2 2301/4885CYP1A2 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.