Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | KRAS | P01116 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24639249 | 1.00 | LTA4H (0.33) | LTA4HKRASALDH1A1CYP2D6TIPARP | |
| SCHEMBL24640205 | 0.88 | PARP1 (0.34) | LTA4HKRASALDH1A1CYP2D6TIPARP | |
| SCHEMBL24640616 | 0.80 | KRAS (0.32) | KRASTIPARP | |
| SCHEMBL24640610 | 0.79 | TIPARP (0.39) | KRASCYP2D6TIPARPKCNH2 | |
| SCHEMBL24639271 | 0.78 | KRAS (0.40) | KRASTIPARP | |
| SCHEMBL31245220 | 0.74 | TIPARP (0.48) | TIPARP | |
| SCHEMBL24640720 | 0.72 | OPRL1 (0.33) | LTA4HOPRL1KCNH2 | |
| SCHEMBL24640215 | 0.71 | NLRP3 (0.33) | LTA4HOPRL1KCNH2 | |
| SCHEMBL24640611 | 0.70 | TIPARP (0.34) | KRASTIPARP | |
| SCHEMBL24640207 | 0.69 | TIPARP (0.31) | KRASTIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |