Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362491 | 0.83 | ESR1 (0.38) | ESR1ESR2MTNR1AMTNR1BRAB9A | |
| SCHEMBL2489539 | 0.78 | CHRM1 (0.37) | PTGS2MTNR1AMTNR1BFPR1KDM4E | |
| SCHEMBL2578644 | 0.76 | ESR1 (0.42) | ESR1ESR2PTGS2RAB9AKDM4E | |
| SCHEMBL2581042 | 0.75 | ESR1 (0.37) | ESR1ESR2PTGS2RAB9AKDM4E | |
| SCHEMBL7910678 | 0.74 | RAB9A (0.40) | ESR1ESR2RAB9AMAPTMEN1 | |
| SCHEMBL2586745 | 0.73 | ESR1 (0.36) | ESR1ESR2RAB9A | |
| SCHEMBL2586818 | 0.72 | ESR1 (0.34) | ESR1ESR2 | |
| SCHEMBL2464402 | 0.71 | ESR1 (0.33) | ESR1ESR2 | |
| SCHEMBL2581768 | 0.71 | ALDH1A1 (0.35) | ESR1ESR2RAB9AKDM4EMAPT | |
| SCHEMBL12175815 | 0.70 | ESR1 (0.31) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364298-A1 | Quinolone compound and pharmaceutical composition | Otsuka Pharmaceutical Co., Ltd. (JP) | 2011-09-14 | — | — | EP | disclosed |