Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PELI1 | Q96FA3 | 3/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535632 | 0.96 | PELI1 (0.57) | PELI1ALOX5ESR2BACE1ESR1 | |
| SCHEMBL1647333 | 0.85 | ALOX5 (0.59) | PELI1ALOX5ESR2BACE1ESR1 | |
| SCHEMBL3062652 | 0.82 | TRIM24 (0.48) | PELI1ESR2ESR1ALDH1A1MEN1 | |
| SCHEMBL8514130 | 0.81 | PELI1 (0.47) | PELI1ESR2ESR1KDM4EALDH1A1 | |
| SCHEMBL6001180 | 0.81 | PELI1 (0.47) | PELI1ESR2ESR1MEN1MAPT | |
| SCHEMBL19153570 | 0.81 | PELI1 (0.47) | PELI1ESR2ESR1KDM4EALDH1A1 | |
| SCHEMBL19910797 | 0.81 | ESR2 (0.51) | PELI1ESR2MEN1MAPTKMT2A | |
| SCHEMBL16555178 | 0.81 | AKR1C3 (0.46) | PELI1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL7074310 | 0.81 | PELI1 (0.60) | PELI1ALOX5ESR2BACE1ESR1 | |
| SCHEMBL9472294 | 0.80 | MEN1 (0.47) | BACE1KDM4EALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654878-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-05-19 | — | — | US | disclosed |
| US-20190031693-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-01-31 | — | — | US | disclosed |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-01-18 | — | — | US | disclosed |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-01-18 | — | — | US | disclosed |
| WO-2017121969-A1 | NOVEL PHOSPHINANE AND AZAPHOSPHINANE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2017-07-20 | — | — | WO | disclosed |
| EP-2582674-B1 | GPR120 RECEPTOR AGONISTS AND USES THEREOF | CYMABAY THERAPEUTICS INC (US) | 2014-10-01 | — | — | EP | disclosed |
| EP-2582674-B1 | GPR120 RECEPTOR AGONISTS AND USES THEREOF | CYMABAY THERAPEUTICS INC (US) | 2014-10-01 | — | — | EP | disclosed |
| US-20140121246-A1 | GPR120 RECEPTOR AGONISTS AND USES THEREOF | METABOLEX, INC. (US) | 2014-05-01 | — | — | US | disclosed |
| US-8598374-B2 | GPR120 receptor agonists and uses thereof | METABOLEX, INC. (US) | 2013-12-03 | — | — | US | disclosed |
| US-8476308-B2 | GPR120 receptor agonists and uses thereof | METABOLEX, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-4522974-A | Melt processable polyester capable of forming an anisotropic melt comprising a relatively low concentration of 6-oxy-2-naphthoyl moiety-4-benzoyl moiety, 1,4-dioxyphenylene moiety, isophthaloyl moiety and terephthaloyl moiety | CELANESE CORPORATION (US) | 1985-06-11 | — | — | US | disclosed |
| US-4473682-A | Melt processable polyester capable of forming an anisotropic melt comprising a relatively low concentration of 6-oxy-2-naphthoyl moiety, 4-oxybenzoyl moiety, 4,4'-dioxybiphenyl moiety, and terephthaloyl moiety | CELANESE CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| EP-0102757-A1 | Fiber-forming polyesters of aromatic ketohydroxy acids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-03-14 | — | — | EP | disclosed |
| EP-0102160-A1 | Anisotropic melt processable polyester comprising relatively low concentration of 6-oxy-2-naphthoyl moiety | CELANESE CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4429100-A | LOW-MELTING, ANISOTROPIC, AROMATIC COPOLYMERS, FIBERS, FILMS | CELANESE CORPORATION (US) | 1984-01-31 | — | — | US | disclosed |
| US-4398015-A | POLYLACTONES; HIGH TENACITY FILAMENTS | E. I. DU PONT DE NEMOURS & COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4299756-A | FIBERS, FILMS, AND MOLDING MATERIALS | CELANESE CORPORATION (US) | 1981-11-10 | — | — | US | disclosed |
| US-4299756-A | FIBERS, FILMS, AND MOLDING MATERIALS | CELANESE CORPORATION (US) | 1981-11-10 | — | — | US | disclosed |
| US-4279803-A | Polyester of phenyl-4-hydroxybenzoic acid and 4-hydroxybenzoic acid and/or 6-hydroxy-2-naphthoic acid capable of forming an anisotropic melt | CELANESE CORPORATION (US) | 1981-07-21 | — | — | US | disclosed |
| US-4279803-A | Polyester of phenyl-4-hydroxybenzoic acid and 4-hydroxybenzoic acid and/or 6-hydroxy-2-naphthoic acid capable of forming an anisotropic melt | CELANESE CORPORATION (US) | 1981-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654878-B2 | Compounds of phosphinanes and azaphosphinanes, a process for their preparation and pharmaceutical compositions containing them | TK1, AK1, PHKA1 | PELI1 3610/4885ALOX5 1963/4885ESR2 2415/4885 |
| US-20140121246-A1 | GPR120 RECEPTOR AGONISTS AND USES THEREOF | GPR119, GPR52, GCGR | PELI1 3332/4885ALOX5 2053/4885ESR2 259/4885 |
| US-20180016288-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TK1, AK1, PHKA1 | PELI1 3610/4885ALOX5 1963/4885ESR2 2415/4885 |
| US-20190031693-A1 | COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AK1, TK1, PHKA1 | PELI1 3827/4885ALOX5 1829/4885ESR2 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.