Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837075 | 0.74 | — | — | |
| SCHEMBL8384 | 0.72 | TSHR (0.35) | TSHRSMN1; SMN2 | |
| SCHEMBL11901033 | 0.72 | F2 (0.30) | — | |
| SCHEMBL998537 | 0.68 | MYC (0.41) | TSHRSMN1; SMN2 | |
| SCHEMBL11489811 | 0.67 | MIF (0.43) | TSHR | |
| SCHEMBL306253 | 0.66 | TSHR (0.37) | TSHRSMN1; SMN2 | |
| SCHEMBL11787881 | 0.64 | SLC16A3 (0.38) | TSHRSMN1; SMN2 | |
| SCHEMBL98562 | 0.61 | TSHR (0.50) | TSHRSMN1; SMN2 | |
| SCHEMBL3940375 | 0.61 | — | — | |
| SCHEMBL10582118 | 0.61 | HDAC8 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3486248-B1 | IMPROVED METHODS FOR THE ACYLATION OF MAYTANSINOL | IMMUNOGEN INC (US) | 2021-04-07 | — | — | EP | claimed |
| EP-3486248-A1 | IMPROVED METHODS FOR THE ACYLATION OF MAYTANSINOL | ImmunoGen, Inc. (US) | 2019-05-22 | — | — | EP | claimed |
| EP-2900676-B1 | IMPROVED METHOD FOR THE ACYLATION OF MAYTANSINOL | IMMUNOGEN INC (US) | 2018-12-19 | — | — | EP | claimed |
| US-9796731-B2 | Methods for the acylation of maytansinol | IMMUNOGEN, INC. (US) | 2017-10-24 | — | — | US | claimed |
| US-20170137440-A1 | METHODS FOR THE ACYLATION OF MAYTANSINOL | IMMUNOGEN SWITZERLAND GMBH (CH) | 2017-05-18 | — | — | US | claimed |
| EP-1390370-B1 | METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS | IMMUNOGEN INC (US) | 2016-04-13 | — | — | EP | claimed |
| EP-2348024-B1 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents | IMMUNOGEN INC (US) | 2015-07-29 | — | — | EP | claimed |
| US-8618042-B2 | Binding molecules and methods of use thereof | BIOGEN IDEC MA INC. (US) | 2013-12-31 | — | — | US | claimed |
| EP-1463558-B1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN INC (US) | 2012-06-06 | — | — | EP | claimed |
| EP-2348024-A2 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents | ImmunoGen, Inc. (US) | 2011-07-27 | — | — | EP | claimed |
| EP-1390370-A4 | METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS | IMMUNOGEN INC (US) | 2005-07-06 | — | — | EP | claimed |
| JP-2005517032-A | — | — | 2005-06-09 | — | — | JP | claimed |
| EP-1463558-A2 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | Immunogen, Inc. (US) | 2004-10-06 | — | — | EP | claimed |
| US-6716821-B2 | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same | IMMUNOGEN INC. | 2004-04-06 | — | — | US | claimed |
| EP-1390370-A1 | METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS | Immunogen, Inc. (US) | 2004-02-25 | — | — | EP | claimed |
| US-20040001838-A1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN, INC. | 2004-01-01 | — | — | US | claimed |
| WO-2003068144-A2 | CYTOTOXIC AGENTS | IMMUNOGEN, INC. (US) | 2003-08-21 | — | — | WO | claimed |
| US-20030055226-A1 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents | IMMUNOGEN, INC. | 2003-03-20 | — | — | US | claimed |
| WO-2002098883-A1 | METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS | IMMUNOGEN, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| US-6441163-B1 | COUPLING MAYTANSINOIDS HAVING DISULFIDE LINKER BEARING REACTIVE MOIETY TO SUCH AS ANTIBODIES WITHOUT PRIOR MODIFICATION OF SAID ANTIBODY; ONE-STEP, HIGH YIELD, LOWER COST | IMMUNOGEN, INC. | 2002-08-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055226-A1 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents | SPR, SELPLG, CD2BP2 | TSHR 2205/4885SMN1; SMN2 1810/4885 |
| US-20170137440-A1 | METHODS FOR THE ACYLATION OF MAYTANSINOL | NAAA, NPPA, AANAT | TSHR 3484/4885SMN1; SMN2 1907/4885 |
| US-20040001838-A1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | MCL1, CD47, BAX | TSHR 2602/4885SMN1; SMN2 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.