Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465627 | 1.00 | ALDH1A1 (0.45) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL2133252 | 0.83 | ADRA2A (0.41) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL22636823 | 0.79 | MAPT (0.55) | ALDH1A1RAB9AMAPTNPSR1HCAR3 | |
| SCHEMBL6609844 | 0.79 | ALDH1A1 (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1507617 | 0.79 | ALDH1A1 (0.49) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL2465151 | 0.78 | GABRA1 (0.36) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL21753178 | 0.77 | GABRA1 (0.37) | ALDH1A1MAPTKMT2AGAAMEN1 | |
| SCHEMBL6510043 | 0.77 | VCAM1 (0.39) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL21753062 | 0.76 | PDK1 (0.43) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1704376 | 0.75 | ALDH1A1 (0.71) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367599-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | Massachusetts Institute of Technology (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065117-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | WO | disclosed |