Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 5/20 | 0.37 |
| ▸ | MAOB | P27338 | 5/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24654868 | 0.87 | DYRK1A (0.56) | DYRK1AGSK3BNFATC1HASPINS1PR1 | |
| SCHEMBL13041963 | 0.81 | HTR6 (0.48) | DYRK1AGSK3BNFATC1HASPINMAOA | |
| SCHEMBL19869619 | 0.80 | BRD4 (0.44) | DYRK1AGSK3BNFATC1TGFBR1CYP2D6 | |
| SCHEMBL19869985 | 0.80 | BRD4 (0.46) | DYRK1AGSK3BNFATC1TGFBR1CYP2D6 | |
| SCHEMBL22482127 | 0.76 | HASPIN (0.61) | DYRK1AGSK3BNFATC1HASPINS1PR1 | |
| SCHEMBL21893483 | 0.76 | DYRK1A (0.46) | DYRK1AGSK3BNFATC1HASPINMAOA | |
| SCHEMBL20674195 | 0.76 | DYRK1A (0.46) | DYRK1AGSK3BNFATC1HASPINS1PR1 | |
| SCHEMBL8738068 | 0.75 | GPR84 (0.52) | — | |
| SCHEMBL24654861 | 0.73 | DYRK1A (0.44) | DYRK1AGSK3BNFATC1HASPINMAOA | |
| SCHEMBL10313372 | 0.72 | MAOA (0.32) | DYRK1AGSK3BNFATC1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
| US-20220332713-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332713-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | DYRK1A 2576/4885GSK3B 948/4885NFATC1 4595/4885 |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | DYRK1A 2576/4885GSK3B 948/4885NFATC1 4595/4885 |
| US-11820766-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | DYRK1A 2576/4885GSK3B 948/4885NFATC1 4595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.