Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 3/20 | 0.36 |
| ▸ | BIRC3 | Q13489 | 3/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.36 |
| ▸ | BIRC8 | Q96P09 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24666347 | 0.89 | TACR1 (0.41) | TACR1CFDDPP8DPP7AADAT | |
| SCHEMBL24664657 | 0.86 | CFD (0.36) | CFDXIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL29820424 | 0.86 | CFD (0.36) | CFDXIAPBIRC3BIRC2BIRC8 | |
| SCHEMBL26833084 | 0.84 | CFD (0.41) | TACR1CFDDPP8DPP7FAP | |
| SCHEMBL26832888 | 0.84 | TACR1 (0.40) | TACR1CFDDPP8DPP7FAP | |
| SCHEMBL26856428 | 0.83 | TACR1 (0.42) | TACR1CFDDPP8DPP7XIAP | |
| SCHEMBL24665904 | 0.83 | CFD (0.47) | TACR1CFDDPP8DPP7AADAT | |
| SCHEMBL29231340 | 0.83 | CFD (0.47) | TACR1CFDDPP8DPP7AADAT | |
| SCHEMBL26832850 | 0.80 | FAP (0.44) | TACR1CFDDPP8DPP7AADAT | |
| SCHEMBL26833067 | 0.80 | CFD (0.40) | TACR1CFDDPP8DPP7AADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814367-B2 | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof | MAZE THERAPEUTICS, INC. (US) | 2023-11-14 | — | — | US | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11814367-B2 | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof | GYS2, GYS1, PYGL | TACR1 4794/4885CFD 4871/4885DPP8 3479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.