SCHEMBL2467064

SCHEMBL2467064

CC(C)OC(=O)c1nc(C2CC2)nc(N)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 3/20 0.45
ALDH1A1 P00352 4/20 0.37
PDE8B O95263 1/20 0.34
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
GAA P10253 1/20 0.31
KDM4E B2RXH2 1/20 0.31
RAB9A P51151 1/20 0.31
CACNA1B Q00975 1/20 0.31
APBA1 Q02410 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
GRM1 Q13255 1/20 0.30
ALOX15 P16050 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL121762 0.84 PDE10A (0.49) PDE10AALDH1A1GAAKDM4EKMT2A
SCHEMBL29615012 0.84 PDE10A (0.49) PDE10AALDH1A1GAAKDM4EKMT2A
Hydrochloric Acid SCHEMBL28163034 0.83 PDE10A (0.47) PDE10AALDH1A1GAAKDM4EKMT2A
SCHEMBL1535606 0.81 PDE10A (0.49) PDE10AALDH1A1MAPTHPGDGAA
SCHEMBL21614312 0.78 PDE10A (0.43) PDE10AALDH1A1HPGDGAAKDM4E
SCHEMBL3693834 0.78 MAPT (0.46) PDE10AALDH1A1MAPTGAAKMT2A
SCHEMBL29372042 0.77 PDE10A (0.46) PDE10APDE8B
SCHEMBL287902 0.77 PDE10A (0.46) PDE10APDE8B
SCHEMBL3681154 0.76 L3MBTL1 (0.53) PDE10AALDH1A1MAPTGAAKDM4E
SCHEMBL16245461 0.76 PDE10A (0.45) PDE10APDE8B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102227165-A Herbicide/safener combination BAYER CROPSCIENCE AG 2011-10-26 CN claimed
EP-2369931-A2 HERBICIDE/SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP claimed
US-20100285959-A1 HERBICIDAL MIXTURES ARMEL GREGORY RUSSELL 2010-11-11 US claimed
US-20100137139-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US claimed
WO-2010060578-A2 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO claimed
EP-2191720-A1 Herbicide-safener combination Bayer CropScience AG (DE) 2010-06-02 EP claimed
US-20090247404-A1 METHOD FOR IMPROVING HARVESTABILITY OF CROPS ANGIOTECH PHARMACEUTICALS, INC. (CA) 2009-10-01 US claimed
CN-101420852-A Herbicidal mixtures DU PONT (US) 2009-04-29 CN claimed
EP-2003972-A2 HERBICIDAL MIXTURES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-12-24 EP claimed
WO-2007120706-A2 HERBICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-10-25 WO claimed
CN-102227165-A Herbicide/safener combination BAYER CROPSCIENCE AG 2011-10-26 CN disclosed
EP-2369931-A2 HERBICIDE/SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
US-20100285959-A1 HERBICIDAL MIXTURES ARMEL GREGORY RUSSELL 2010-11-11 US disclosed
US-20100137139-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed
WO-2010060578-A2 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191720-A1 Herbicide-safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed
US-20090247404-A1 METHOD FOR IMPROVING HARVESTABILITY OF CROPS ANGIOTECH PHARMACEUTICALS, INC. (CA) 2009-10-01 US disclosed
CN-101420852-A Herbicidal mixtures DU PONT (US) 2009-04-29 CN disclosed
WO-2007092184-A2 METHOD FOR IMPROVING HARVESTABILITY OF CROPS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-08-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247404-A1 METHOD FOR IMPROVING HARVESTABILITY OF CROPS AMY1A, DDT, ACHE PDE10A 783/4885ALDH1A1 918/4885PDE8B 945/4885
US-20100285959-A1 HERBICIDAL MIXTURES CYP2D6, DDT, FDPS PDE10A 4607/4885ALDH1A1 837/4885PDE8B 2070/4885
US-20100137139-A1 HERBICIDE/SAFENER COMBINATION CYP2W1, DDT, CBR3 PDE10A 2451/4885ALDH1A1 551/4885PDE8B 3345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.