SCHEMBL246716

SCHEMBL246716

[CH2]CCS(=O)(=O)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSIP1 O75475 1/20 0.56
HSD11B1 P28845 6/20 0.52
L3MBTL1 Q9Y468 1/20 0.47
HTR6 P50406 1/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
MAPT P10636 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL245358 0.86 PSIP1 (0.52) PSIP1HSD11B1L3MBTL1HTR6KEAP1
SCHEMBL777601 0.85 PSIP1 (0.67) PSIP1HSD11B1L3MBTL1HTR6KEAP1
SCHEMBL7328957 0.85 KEAP1 (0.54) PSIP1HSD11B1L3MBTL1KEAP1NFE2L2
SCHEMBL5077217 0.83 HDAC1 (0.56) PSIP1HSD11B1L3MBTL1KEAP1NFE2L2
SCHEMBL7330137 0.83 HDAC1 (0.56) PSIP1HSD11B1L3MBTL1KEAP1NFE2L2
SCHEMBL1540593 0.81 PSIP1 (0.56) PSIP1HSD11B1L3MBTL1HTR6KEAP1
SCHEMBL576918 0.80 KEAP1 (0.63) PSIP1HSD11B1L3MBTL1HTR6KEAP1
SCHEMBL40519 0.80 PSIP1 (0.61) PSIP1HSD11B1HTR6MAPTPOLB
SCHEMBL10629823 0.80 PSIP1 (0.61) PSIP1HSD11B1L3MBTL1HTR6KEAP1
Hydrochloric Acid SCHEMBL1977191 0.79 PSIP1 (0.54) PSIP1HSD11B1L3MBTL1HTR6KEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115148643-A Wet etching equipment and wet etching method 中国科学院上海微系统与信息技术研究所 2022-10-04 CN claimed
CN-110105237-B Beta-gem-difluoro azide compound and preparation and application thereof 东北师范大学 2021-12-24 CN claimed
EP-1696912-B1 PYRAZOLOPYRIDINES AND ANALOGS THEREOF 3M INNOVATIVE PROPERTIES CO (US) 2016-05-11 EP claimed
US-9145410-B2 Pyrazolopyridines and analogs thereof 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-09-29 US claimed
EP-2161573-B1 MONOLITH ADSORBENT AND METHOD AND APPARATUS FOR ADSORBING SAMPLES WITH THE SAME GL SCIENCES INC (JP) 2014-10-01 EP claimed
US-8795410-B2 Monolith adsorbent and method and apparatus for adsorbing samples with the same GL SCIENCES INCORPORATED (JP) 2014-08-05 US claimed
EP-2197879-B1 C7-SUBSTITUTED CAMPTOTHECIN ANALOGS BIONUMERIK PHARMACEUTICALS INC (US) 2014-01-22 EP claimed
US-20120121651-A1 PYRAZOLOPYRIDINES AND ANALOGS THEREOF 3M INNOVATIVE PROPERTIES COMPANY 2012-05-17 US claimed
US-20110023711-A1 MONOLITH ADSORBENT AND METHOD AND APPARATUS FOR ADSORBING SAMPLES WITH THE SAME GL SCIENCE INCORPORATED (JP) 2011-02-03 US claimed
US-7879849-B2 such as 1-(2-Methylpropyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine, used as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of viral and neoplastic diseases 3M INNOVATIVE PROPERTIES COMPANY (US) 2011-02-01 US claimed
EP-1696912-A2 PYRAZOLOPYRIDINES AND ANALOGS THEREOF 3M Innovative Properties Company (US) 2006-09-06 EP claimed
WO-2006091647-A2 METHOD OF PREFERENTIALLY INDUCING THE BIOSYNTHESIS OF INTERFERON COLEY PHARMACEUTICAL GROUP, INC. (US) 2006-08-31 WO claimed
WO-2005079195-A2 PYRAZOLOPYRIDINES AND ANALOGS THEREOF 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-09-01 WO claimed
US-20050100959-A1 Device and method for detecting the presence of an analyte UNIVERSITEIT GENT (BE) 2005-05-12 US claimed
EP-1360480-A2 DEVICE AND METHOD FOR DETECTING THE PRESENCE OF AN ANALYTE UNIVERSITEIT GENT (BE) 2003-11-12 EP claimed
WO-2002065115-A2 DEVICE AND METHOD FOR DETECTING THE PRESENCE OF AN ANALYTE UNIVERSITEIT GENT (BE) 2002-08-22 WO claimed
CN-1320123-A Disubstituted maleimide compounds and medicinal utilization thereof JAPAN TOBACCO INC (JP) 2001-10-31 CN claimed
EP-0920414-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 1999-06-09 EP claimed
WO-1997049674-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1997-12-31 WO claimed
US-5272094-A Isolation of components from biological specimens via matrix solid phase dispersion BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 1993-12-21 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120121651-A1 PYRAZOLOPYRIDINES AND ANALOGS THEREOF IL4, IL4I1, IL2 PSIP1 388/4885HSD11B1 4704/4885L3MBTL1 3975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.