SCHEMBL24676679

SCHEMBL24676679

CC(C)(C)[Si](C)(C)OCCc1nc(C(F)(F)F)cs1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 1/20 0.32
MCHR1 Q99705 1/20 0.30
DUT P33316 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24675970 0.84 L3MBTL1 (0.36) MEN1KMT2ALMNAMCHR1
SCHEMBL18758330 0.78 DUT (0.31) DUT
SCHEMBL20536461 0.76 HDAC1 (0.32) DUT
SCHEMBL18758336 0.76 HDAC1 (0.34) DUT
SCHEMBL28860776 0.75 LMNA (0.36) MEN1KMT2ALMNAMCHR1
SCHEMBL27713054 0.74 HDAC1 (0.32) MEN1KMT2AMCHR1
SCHEMBL24676752 0.72 MEN1 (0.32) MEN1KMT2A
SCHEMBL16592085 0.72 SLC6A3 (0.39) MEN1KMT2ALMNAMCHR1
SCHEMBL24676686 0.72 TKT (0.35) MEN1KMT2ALMNA
SCHEMBL19370158 0.72 LOXL2 (0.46) MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155941-A1 CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-07-28 WO disclosed
WO-2022155941-A1 CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-07-28 WO disclosed