Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24746198 | 0.84 | RAB9A (0.44) | RAB9ANPC1KMT2AHSD11B1GRM5 | |
| SCHEMBL15458881 | 0.78 | RAB9A (0.40) | RAB9ANPC1KMT2AHDAC6GRM5 | |
| SCHEMBL24746302 | 0.76 | RAB9A (0.36) | RAB9ANPC1KMT2AHSD11B1GRM5 | |
| SCHEMBL19480253 | 0.74 | HSD11B1 (0.39) | KMT2AHSD11B1HDAC1HDAC6CHRM1 | |
| SCHEMBL31052658 | 0.73 | MGLL (0.46) | RAB9ANPC1KMT2AHSD11B1GRM5 | |
| SCHEMBL20070592 | 0.73 | HDAC1 (0.44) | KMT2AHSD11B1HDAC1HDAC6CHRM1 | |
| SCHEMBL17559438 | 0.73 | PRMT5 (0.47) | KMT2AHSD11B1HDAC1HDAC6CHRM1 | |
| SCHEMBL549310 | 0.73 | GRIA3 (0.51) | RAB9ANPC1KMT2AGRM5ALDH1A1 | |
| SCHEMBL19869691 | 0.72 | BRD4 (0.54) | RAB9ANPC1GRM5 | |
| SCHEMBL10203502 | 0.71 | L3MBTL1 (0.56) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |