Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24754239 | 0.81 | KMT2A (0.42) | KMT2AALDH1A1HPGDSMN1; SMN2DRD2 | |
| SCHEMBL24754590 | 0.75 | IDO1 (0.40) | KMT2ATBXAS1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24754231 | 0.75 | IDO1 (0.40) | KMT2ATBXAS1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24754234 | 0.74 | CYP1A2 (0.40) | KMT2ATBXAS1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24754238 | 0.70 | TDP1 (0.59) | KMT2AALDH1A1HPGDSMN1; SMN2DRD2 | |
| SCHEMBL24754395 | 0.69 | BRD4 (0.42) | KMT2ATBXAS1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL22091411 | 0.69 | ALDH1A1 (0.45) | TBXAS1ALDH1A1HPGDSMN1; SMN2DRD2 | |
| SCHEMBL22091425 | 0.69 | ALDH1A1 (0.45) | TBXAS1ALDH1A1HPGDSMN1; SMN2DRD2 | |
| SCHEMBL24754227 | 0.69 | HDAC1 (0.44) | KMT2ATBXAS1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24754230 | 0.69 | TBXAS1 (0.43) | KMT2ATBXAS1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263829-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |