Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24754239 | 0.81 | KMT2A (0.42) | IDO1TDO2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24754228 | 0.75 | KMT2A (0.39) | IDO1TDO2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22091411 | 0.75 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HPGDDRD2KCNH2 | |
| SCHEMBL22091425 | 0.75 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HPGDDRD2KCNH2 | |
| SCHEMBL24754234 | 0.74 | CYP1A2 (0.40) | IDO1TDO2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24754590 | 0.72 | IDO1 (0.40) | IDO1TDO2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24754233 | 0.72 | BRD4 (0.42) | IDO1TDO2ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24754230 | 0.71 | TBXAS1 (0.43) | ALDH1A1SMN1; SMN2HPGDKMT2ATBXAS1 | |
| SCHEMBL24754241 | 0.70 | LMNA (0.67) | ALDH1A1SMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL24754227 | 0.69 | HDAC1 (0.44) | ALDH1A1SMN1; SMN2HPGDDRD2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263829-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |