Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248344 | 1.00 | NPSR1 (0.44) | NPSR1ALDH1A1HTTHSD17B10TDP1 | |
| SCHEMBL2080613 | 0.83 | ALDH1A1 (0.47) | NPSR1ALDH1A1HTTHSD17B10TDP1 | |
| SCHEMBL9210396 | 0.82 | ALDH1A1 (0.43) | NPSR1ALDH1A1HTTHSD17B10TDP1 | |
| SCHEMBL17556135 | 0.79 | KIF18A (0.46) | NPSR1ALDH1A1TSHRL3MBTL1MAPT | |
| SCHEMBL652038 | 0.79 | HCAR3 (0.44) | ALDH1A1HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL652037 | 0.79 | HCAR3 (0.44) | ALDH1A1HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL17556134 | 0.79 | KIF18A (0.46) | NPSR1ALDH1A1TSHRL3MBTL1MAPT | |
| SCHEMBL601391 | 0.78 | ATM (0.46) | ALDH1A1HSD17B10TDP1TSHRL3MBTL1 | |
| SCHEMBL601392 | 0.78 | ATM (0.46) | ALDH1A1HSD17B10TDP1TSHRL3MBTL1 | |
| SCHEMBL2219445 | 0.78 | AKR1C3 (0.46) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266822-B2 | Solid forms of tacedinaline | THE BROAD INSTITUTE, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-8841346-B2 | Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-09-23 | — | — | US | disclosed |
| US-20140275268-A1 | NOVEL SOLID FORMS OF TACEDINALINE | THE BROAD INSTITUTE, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8729130-B2 | Methods of using novel solid forms of tacedinaline | THE BROAD INSTITUTE, INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8563615-B2 | Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-22 | — | — | US | disclosed |
| US-20130150450-A1 | NOVEL SOLID FORMS OF TACEDINALINE | THE BROAD INSTITUTE, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130102677-A1 | NOVEL SOLID FORMS OF TACEDINALINE | THE BROAD INSTITUTE, INC. (US) | 2013-04-25 | — | — | US | disclosed |
| US-20120322879-A1 | USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2012-12-20 | — | — | US | disclosed |
| EP-2493298-A1 | THE USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS | Massachusetts Institute of Technology (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2012003413-A1 | NOVEL SOLID FORMS OF TACEDINALINE | THE BROAD INSTITUTE, INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| US-20110224303-A1 | USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS | MASSACHUSETTS GENERAL HOSPITAL | 2011-09-15 | — | — | US | disclosed |
| WO-2011053876-A1 | THE USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322879-A1 | USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS | CHRNA4, SLC6A4, CHRNB4 | NPSR1 96/4885ALDH1A1 1595/4885HTT 1356/4885 |
| US-20110224303-A1 | USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS | CHRNA4, SLC6A4, CHRNB4 | NPSR1 96/4885ALDH1A1 1595/4885HTT 1356/4885 |
| US-20130102677-A1 | NOVEL SOLID FORMS OF TACEDINALINE | ACSS2, SLC10A1, ACAT2 | NPSR1 2782/4885ALDH1A1 3839/4885HTT 2263/4885 |
| US-20130150450-A1 | NOVEL SOLID FORMS OF TACEDINALINE | ACSS2, SLC10A1, ACAT2 | NPSR1 2782/4885ALDH1A1 3839/4885HTT 2263/4885 |
| US-20140275268-A1 | NOVEL SOLID FORMS OF TACEDINALINE | ACSS2, FAM162A, ACAT2 | NPSR1 2972/4885ALDH1A1 3973/4885HTT 2590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.