Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GGT1 | P19440 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319617 | 0.85 | TDP1 (0.50) | TDP1L3MBTL1ALDH1A1TSHRGAA | |
| SCHEMBL27581135 | 0.79 | GPR35 (0.42) | ALDH1A1TSHRGAAKDM4ERAB9A | |
| SCHEMBL31571840 | 0.79 | ALDH1A1 (0.46) | TDP1ALDH1A1TSHRGAAKDM4E | |
| SCHEMBL30438328 | 0.76 | TDP1 (0.60) | TDP1L3MBTL1ALDH1A1TSHRRAB9A | |
| SCHEMBL633629 | 0.76 | TDP1 (0.46) | TDP1L3MBTL1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL29154301 | 0.74 | TDP1 (0.45) | TDP1L3MBTL1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3184922 | 0.74 | PPARA (0.56) | TDP1L3MBTL1PTGS2PPARGPPARA | |
| SCHEMBL28077125 | 0.74 | ALDH1A1 (0.54) | TDP1L3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4076795 | 0.74 | L3MBTL1 (0.51) | TDP1L3MBTL1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2532517 | 0.73 | TDP1 (0.44) | TDP1L3MBTL1ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376428-A2 | NEW INHIBITORS FOR TREATING DISEASES ASSOCIATED WITH AN EXCESS TRANSPORT OF HYALURONAN | Universitätsklinikum Münster (DE) | 2011-10-19 | — | — | EP | disclosed |
| US-20110245335-A1 | NEW INHIBITORS FOR TREATING DISEASES ASSOCIATED WITH AN EXCESS TRANSPORT OF HYALURONAN | UNIVERSITAETSKLINIKUM MUENSTER (DE) | 2011-10-06 | — | — | US | disclosed |
| US-20110245335-A1 | NEW INHIBITORS FOR TREATING DISEASES ASSOCIATED WITH AN EXCESS TRANSPORT OF HYALURONAN | UNIVERSITAETSKLINIKUM MUENSTER (DE) | 2011-10-06 | — | — | US | disclosed |
| WO-2010066909-A2 | NEW INHIBITORS FOR TREATING DISEASES ASSOCIATED WITH AN EXCESS TRANSPORT OF HYALURONAN | Universitätsklinikum Münster (DE) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245335-A1 | NEW INHIBITORS FOR TREATING DISEASES ASSOCIATED WITH AN EXCESS TRANSPORT OF HYALURONAN | SLC10A1, ABCB11, HEXD | TDP1 2276/4885L3MBTL1 4466/4885ALDH1A1 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.