Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875680 | 0.81 | LMNA (0.40) | KDM4EHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9876382 | 0.78 | LMNA (0.40) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9876360 | 0.76 | HPGD (0.40) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9876155 | 0.76 | HPGD (0.40) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9876562 | 0.76 | HPGD (0.40) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23363866 | 0.74 | DGAT1 (0.35) | KDM4EHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24662913 | 0.73 | MAPT (0.40) | KDM4EHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24662837 | 0.72 | SMN1; SMN2 (0.34) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3602644 | 0.70 | MAPT (0.36) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL28865246 | 0.70 | ALDH1A1 (0.44) | KDM4EHPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022246459-A9 | COMBINATION THERAPY | GENENTECH, INC. (US) | 2023-01-05 | — | — | WO | disclosed |