Sugi Predict

Sugi Predict / Compounds / SCHEMBL2486578

SCHEMBL2486578

SCHEMBL2486578

O=C(O)c1cc(-c2cccc(Cl)c2)on1

nearest known ligand 0.76

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PTPN1 P18031 1/20 0.76
▸ ALDH1A1 P00352 3/20 0.70
▸ NPC1 O15118 6/20 0.64
▸ RAB9A P51151 6/20 0.64
▸ TP53 P04637 4/20 0.63
▸ THRB P10828 1/20 0.63
▸ HPGD P15428 1/20 0.62
▸ MAPK1 P28482 1/20 0.61
▸ MAPT P10636 3/20 0.61
▸ POLB P06746 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5620215 0.86 PTPN1 (1.00) PTPN1ALDH1A1NPC1RAB9ATP53
SCHEMBL1544185 0.86 MAPK1 (0.64) ALDH1A1NPC1RAB9ATP53THRB
SCHEMBL71299 0.83 ALDH1A1 (1.00) PTPN1ALDH1A1NPC1RAB9AHPGD
SCHEMBL72387 0.82 PTPN1 (0.78) PTPN1ALDH1A1NPC1RAB9ATP53
SCHEMBL1545189 0.82 NOTUM (0.68) ALDH1A1NPC1RAB9ATP53THRB
SCHEMBL892967 0.81 CDH1 (0.82) PTPN1ALDH1A1NPC1RAB9ATP53
SCHEMBL1178549 0.81 PTPN1 (0.76) PTPN1ALDH1A1NPC1RAB9ATP53
SCHEMBL70042 0.81 PTPN1 (0.76) PTPN1ALDH1A1NPC1RAB9AHPGD
SCHEMBL1178606 0.81 PTPN1 (0.76) PTPN1ALDH1A1NPC1RAB9AHPGD
SCHEMBL1227407 0.79 L3MBTL1 (0.73) ALDH1A1NPC1RAB9ATP53THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250346575-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-11-13 — — US disclosed
EP-4431505-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF Korea Research Institute of Chemical Technology (KR) 2024-09-18 — — EP disclosed
CN-118234721-A Isoindolinone derivative with glutarimide mother nucleus and application thereof 韩国化学研究院 2024-06-21 — — CN disclosed
WO-2023085785-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF 한국화학연구원 2023-05-19 — — WO disclosed
US-11434212-B2 Bicyclic compound as a caspase inhibitor CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2022-09-06 — — US disclosed
EP-3572402-B1 LINKED CYCLIC COMPOUND AS CASPASE INHIBITOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2022-05-04 — — EP disclosed
US-20210332019-A1 Bicyclic Compound as a Caspase Inhibitor CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2021-10-28 — — US disclosed
WO-2021073643-A1 DRUG FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS 正大天晴药业集团股份有限公司 2021-04-22 — — WO disclosed
CN-103649066-B 5-carbamyl-diamantane (obsolete)-2-yl amide derivatives, its pharmaceutically acceptable salt and preparation method thereof 爱思开生物制药株式会社 2016-08-17 — — CN disclosed
EP-2699560-B1 5-CARBAMOYL-ADAMANTAN-2-YL AMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND PREPARATION PROCESS THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2016-04-20 — — EP disclosed
US-20080312246-A1 Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists ASTRAZENECA AB (SE) 2008-12-18 — — US disclosed
US-20080312246-A1 Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists ASTRAZENECA AB (SE) 2008-12-18 — — US disclosed
US-20080312246-A1 Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists ASTRAZENECA AB (SE) 2008-12-18 — — US disclosed
CN-101287722-A Substituted piperazines as metabotropic glutamate receptor antagonists ASTRAZENECA AB (SE) 2008-10-15 — — CN disclosed
CN-101273037-A New compounds for the treatment of neurological, psychiatric or pain disorders ASTRAZENECA AB (SE) 2008-09-24 — — CN disclosed
EP-1919901-A1 SUBSTITUTED PIPERAZINES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2008-05-14 — — EP disclosed
WO-2007021573-A1 SUBSTITUTED PIPERAZINES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2007-02-22 — — WO disclosed
US-20070037820-A1 Substituted piperazines as metabotropic glutamate receptor antagonists ASTRAZENECA AB (SE) 2007-02-15 — — US disclosed
US-20070037820-A1 Substituted piperazines as metabotropic glutamate receptor antagonists ASTRAZENECA AB (SE) 2007-02-15 — — US disclosed
US-20070037820-A1 Substituted piperazines as metabotropic glutamate receptor antagonists ASTRAZENECA AB (SE) 2007-02-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11434212-B2 Bicyclic compound as a caspase inhibitor CASP1, CASP14, CASP2 PTPN1 4110/4885ALDH1A1 3348/4885NPC1 1000/4885
US-20080312246-A1 Substituted Piperazines as Metabotropic Glutamate Receptor Antagonists GRM5, GRM1, GRM2 PTPN1 1307/4885ALDH1A1 909/4885NPC1 907/4885
US-20210332019-A1 Bicyclic Compound as a Caspase Inhibitor CASP1, CASP14, CASP2 PTPN1 4110/4885ALDH1A1 3348/4885NPC1 1000/4885
US-20250346575-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF CRBN, IDH1, IDH2 PTPN1 1412/4885ALDH1A1 849/4885NPC1 3359/4885
US-20070037820-A1 Substituted piperazines as metabotropic glutamate receptor antagonists GRM5, GRM1, GRM2 PTPN1 1307/4885ALDH1A1 909/4885NPC1 907/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.