Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.53 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867261 | 0.85 | MAP4K1 (0.42) | AOC3POLB | |
| SCHEMBL24867263 | 0.79 | MAPK1 (0.56) | AOC3 | |
| SCHEMBL24867273 | 0.79 | AOC3 (0.36) | AOC3DYRK1A | |
| SCHEMBL24867264 | 0.79 | AOC3 (0.36) | AOC3DYRK1A | |
| SCHEMBL24866922 | 0.78 | MAPK1 (0.36) | AOC3 | |
| SCHEMBL24866931 | 0.78 | AOC3 (0.38) | AOC3 | |
| SCHEMBL24867267 | 0.77 | DYRK1A (0.41) | AOC3DYRK1A | |
| SCHEMBL3312007 | 0.71 | ROCK2 (0.61) | ROCK2ROCK1NAMPTPRKD1DYRK1A | |
| SCHEMBL1716536 | 0.70 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL24866871 | 0.68 | MAPK3 (0.36) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |