Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867261 | 0.84 | MAP4K1 (0.42) | AOC3HDAC1 | |
| SCHEMBL24866931 | 0.84 | AOC3 (0.38) | MAPK1AOC3MAPK3PIK3C3PIK3CD | |
| SCHEMBL24866922 | 0.84 | MAPK1 (0.36) | MAPK1AOC3MAPK3PIK3C3PIK3CD | |
| SCHEMBL24867267 | 0.83 | DYRK1A (0.41) | MAPK1AOC3MAPK3MKNK1MAPK8 | |
| SCHEMBL23408943 | 0.82 | MAPK1 (0.67) | MAPK1AOC3MAPK3KCNH2 | |
| SCHEMBL24867264 | 0.80 | AOC3 (0.36) | MAPK1AOC3MAPK8MAPK9 | |
| SCHEMBL24867273 | 0.80 | AOC3 (0.36) | MAPK1AOC3MAPK8MAPK9 | |
| SCHEMBL24867265 | 0.79 | ROCK2 (0.53) | AOC3 | |
| SCHEMBL16067939 | 0.74 | HDAC1 (0.52) | MAPK1AOC3MAPK3PIK3C3PIK3CD | |
| SCHEMBL19144932 | 0.73 | MAPK1 (1.00) | MAPK1AOC3MAPK3PIK3C3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |