Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491875 | 0.90 | KMT2A (0.57) | CYP2C19MEN1KMT2ACYP3A4L3MBTL1 | |
| SCHEMBL2491083 | 0.87 | CNR2 (0.51) | TDP1CYP2C19MEN1KMT2ACYP3A4 | |
| SCHEMBL2488953 | 0.83 | CYP2C9 (0.46) | CYP2C19CYP2D6MEN1KMT2ACYP2C9 | |
| SCHEMBL9427609 | 0.78 | ACP3 (0.50) | CYP2C19CYP2D6MEN1KMT2ACYP1A2 | |
| SCHEMBL8430372 | 0.78 | ACP3 (0.50) | CYP2C19CYP2D6MEN1KMT2ACYP1A2 | |
| SCHEMBL5273602 | 0.77 | CYP1A2 (0.62) | TDP1CYP2C19CYP2D6MEN1KMT2A | |
| SCHEMBL10572282 | 0.77 | KMT2A (0.70) | TDP1CYP2C19CYP2D6MEN1KMT2A | |
| SCHEMBL6462875 | 0.77 | GABRB1 (0.51) | TDP1CYP2C19CYP2D6MEN1KMT2A | |
| SCHEMBL2524937 | 0.76 | TSHR (0.47) | CYP2C19CYP2D6MEN1KMT2ACYP2C9 | |
| SCHEMBL20442882 | 0.76 | MAPT (0.54) | CYP2C19CYP2D6MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8624051-B2 | Process for the preparation of isoserine derivatives | INDENA S.P.A. (IT) | 2014-01-07 | — | — | US | disclosed |
| US-20130090493-A1 | PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | INDENA S.P.A (IT) | 2013-04-11 | — | — | US | disclosed |
| EP-2558439-A1 | A PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | Indena S.p.A. (IT) | 2013-02-20 | — | — | EP | disclosed |
| EP-2380871-B1 | A process for the preparation of isoserine derivatives | INDENA SPA (IT) | 2013-01-09 | — | — | EP | disclosed |
| EP-2380871-A1 | A process for the preparation of isoserine derivatives | Indena S.p.A. (IT) | 2011-10-26 | — | — | EP | disclosed |
| WO-2011128353-A1 | A PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | INDENA S.P.A. (IT) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090493-A1 | PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | ICMT, PGLS, PCMT1 | TDP1 3874/4885CYP2C19 3304/4885CYP2D6 3029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.