Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491875 | 0.82 | KMT2A (0.57) | CYP3A4CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL2491083 | 0.76 | CNR2 (0.51) | TSHRCYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL2487337 | 0.76 | TDP1 (0.49) | CYP3A4CYP2C19CYP2D6CYP2C9MEN1 | |
| SCHEMBL14039791 | 0.76 | LMNA (0.40) | TSHRCYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL20442882 | 0.76 | MAPT (0.54) | TSHRCYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL6712871 | 0.75 | ESR1 (0.47) | TSHRCYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2488953 | 0.73 | CYP2C9 (0.46) | CYP2C19CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL9000694 | 0.72 | CES2 (0.56) | TSHRCYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL7997322 | 0.72 | KMT2A (0.58) | CYP3A4CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL2485290 | 0.71 | MAPT (0.49) | MEN1KMT2AMAPTL3MBTL1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8624051-B2 | Process for the preparation of isoserine derivatives | INDENA S.P.A. (IT) | 2014-01-07 | — | — | US | disclosed |
| US-20130090493-A1 | PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | INDENA S.P.A (IT) | 2013-04-11 | — | — | US | disclosed |
| EP-2558439-A1 | A PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | Indena S.p.A. (IT) | 2013-02-20 | — | — | EP | disclosed |
| EP-2380871-B1 | A process for the preparation of isoserine derivatives | INDENA SPA (IT) | 2013-01-09 | — | — | EP | disclosed |
| EP-2380871-A1 | A process for the preparation of isoserine derivatives | Indena S.p.A. (IT) | 2011-10-26 | — | — | EP | disclosed |
| WO-2011128353-A1 | A PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | INDENA S.P.A. (IT) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090493-A1 | PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES | ICMT, PGLS, PCMT1 | TSHR 2428/4885CYP3A4 2084/4885CYP2C19 3304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.