Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 7/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 7/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.35 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.35 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL7048263 | 0.91 | KDM4E (0.34) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL12224094 | 0.88 | SIRT6 (0.37) | KDM4EALDH1A1TSHRASPHKDM8 | |
| SCHEMBL9317147 | 0.86 | ALDH1A1 (0.33) | KDM4EALDH1A1ASPHKDM8KLKB1 | |
| SCHEMBL9315383 | 0.86 | KDM4E (0.38) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL28281331 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL2486333 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL7052671 | 0.81 | KDM4E (0.40) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL351540 | 0.81 | GABRP (0.46) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL7471367 | 0.81 | KDM4E (0.40) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL3086351 | 0.80 | GABRP (0.45) | KDM4EALDH1A1TSHRCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376472-A1 | PROCESS FOR MANUFACTURING 5-FORMYL-PYRIDINE-2,3-DICARBOXYLIC ACID ESTERS | BASF SE (DE) | 2011-10-19 | — | — | EP | claimed |
| WO-2010066668-A1 | PROCESS FOR MANUFACTURING 5-FORMYL-PYRIDINE-2,3-DICARBOXYLIC ACID ESTERS | BASF SE (DE) | 2010-06-17 | — | — | WO | claimed |
| EP-0601288-B1 | Substituted 2,3-dicarboxypyridinium nitrates | BASF AG (DE) | 2003-05-02 | — | — | EP | claimed |
| EP-0461402-B1 | Process for the preparation of substituted and unsubstituted 2,3-pyridinedicarboxylates from chloromaleate or chlorofumarate or mixtures thereof | AMERICAN CYANAMID CO (US) | 1998-07-15 | — | — | EP | claimed |
| CN-1038507-C | Process for preparation of substituted and unsubstituted-2,3-pyridinedicarboxylates from chloromaleate or chlorofumarate or mixtures thereof | AMERICAN CYANAMID CO (US) | 1998-05-27 | — | — | CN | claimed |
| CN-1038414-C | Process for preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichlorosucciate | AMERICAN CYANAMID CO (US) | 1998-05-20 | — | — | CN | claimed |
| EP-0461403-B1 | Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosucciante | AMERICAN CYANAMID CO (US) | 1996-08-28 | — | — | EP | claimed |
| EP-0560019-B1 | Process for the preparation of dialkyl 2,3-pyridinedicarboxylate and derivatives thereof from an alpha, beta-unsaturated oxime and an aminobutenedioate | AMERICAN CYANAMID CO (US) | 1996-04-24 | — | — | EP | claimed |
| EP-0560019-A1 | Process for the preparation of dialkyl 2,3-pyridinedicarboxylate and derivatives thereof from an alpha, beta-unsaturated oxime and an aminobutenedioate | AMERICAN CYANAMID COMPANY (US) | 1993-09-15 | — | — | EP | claimed |
| US-5227491-A | Process for the preparation of dialkyl 2,3-pyridinedicarboxylate and derivatives thereof from an α,β-unsaturated oxime and an aminobutenedioate | AMERICAN CYANAMID COMPANY (US) | 1993-07-13 | — | — | US | claimed |
| US-5225560-A | Dehydrohalogenation | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | claimed |
| EP-0548559-A1 | Process for the preparation of dialkyl pyridine -2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate | AMERICAN CYANAMID COMPANY (US) | 1993-06-30 | — | — | EP | claimed |
| CN-1062724-A | Replace or do not have replacement-2, the method for 3-pyridine dicarboxylate by chloromaleic acid ester or chlorofumaric acid ester or the preparation of its mixture | AMERICAN CYANAMID CO (US) | 1992-07-15 | — | — | CN | claimed |
| US-5124458-A | Reacting a dialkyldichlorosuccinate with a dehydrohalogenating agent, treating the reaction product with ammonia, treating the new reaction product with an unsaturated aldehyde or ketone | AMERICAN CYANAMID COMPANY (US) | 1992-06-23 | — | — | US | claimed |
| US-5118809-A | Mixing with ammonium salt and unsaturated aldehydes or ketones | AMERICAN CYANAMID COMPANY (US) | 1992-06-02 | — | — | US | claimed |
| CN-1057455-A | Prepare pyridine-2 by dichloro succinate dialkyl ester, the method for 3-dicarboxylic acid dialkyl esters and derivative thereof | AMERICAN CYANAMID CO (US) | 1992-01-01 | — | — | CN | claimed |
| CN-1057456-A | Prepare pyridine-2 by the dichloro-dialkyl maleate, the method for 3-dicarboxylic acid dialkyl esters and derivative thereof | AMERICAN CYANAMID CO (US) | 1992-01-01 | — | — | CN | claimed |
| EP-0461403-A1 | Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosucciante | AMERICAN CYANAMID COMPANY (US) | 1991-12-18 | — | — | EP | claimed |
| EP-0461401-A1 | Process for the preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate | AMERICAN CYANAMID COMPANY (US) | 1991-12-18 | — | — | EP | claimed |
| EP-0461402-A1 | Process for the preparation of substituted and unsubstituted 2,3-pyridinedicarboxylates from chloromaleate or chlorofumarate or mixtures thereof | AMERICAN CYANAMID COMPANY (US) | 1991-12-18 | — | — | EP | claimed |