SCHEMBL24910232

SCHEMBL24910232

CC(C)c1ccccc1-c1ccccc1C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 4/20 0.52
HSD11B1 P28845 5/20 0.46
P2RX7 Q99572 1/20 0.44
AKR1C3 P42330 1/20 0.44
AKR1C2 P52895 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
ALDH1A1 P00352 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41
CYP2C19 P33261 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TRPM8 Q7Z2W7 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
NOTUM Q6P988 1/20 0.40
AR P10275 1/20 0.39
PTPN5 P54829 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL84477 0.83 P2RX7 (0.50) TRPA1HSD11B1P2RX7SMN1; SMN2ALDH1A1
SCHEMBL24910426 0.83 TRPA1 (0.52) TRPA1HSD11B1AKR1C3AKR1C2SMN1; SMN2
SCHEMBL16147411 0.80 TRPA1 (0.38) TRPA1HSD11B1P2RX7AKR1C3AKR1C2
SCHEMBL167078 0.80 GABRA1 (0.55) TRPA1SMN1; SMN2ALDH1A1CYP3A4CYP2D6
SCHEMBL197671 0.80 HSD11B1 (0.56) TRPA1HSD11B1ALDH1A1CYP3A4CYP2D6
SCHEMBL29414063 0.80 GABRA1 (0.55) TRPA1SMN1; SMN2ALDH1A1CYP3A4CYP2D6
SCHEMBL10094520 0.78 CYP3A4 (0.54) TRPA1HSD11B1ALDH1A1CYP3A4CYP2C19
SCHEMBL28295774 0.78 ADRA1A (0.43) TRPA1HSD11B1P2RX7ALDH1A1CYP3A4
SCHEMBL8022901 0.78 HSD11B1 (0.54) TRPA1HSD11B1ALDH1A1CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL29010139 0.78 HSD11B1 (0.54) TRPA1HSD11B1ALDH1A1CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4122934-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-01-25 EP disclosed